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BioCrys2012

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The sixth BioCrys course will be focused on Macromolecular Crystallography, by developing the fundamental concepts of Crystallography and illustrate these by tutorial and practical sessions.

When 20 Oct, 2012 09:00 AM to
27 Oct, 2012 05:00 PM
Where Auditorium
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Programme

Day 1 - 20 Oct 2012 - Saturday
09.00-10.00 - Basics of Crystallography - Edward Hough
10.00-10.20 - Coffee Break
10.20-10.45 - Introduction to the computing and network infrastructure – Pedro Matias
10.45-11.45 - X-ray sources - Christoph Hermes
12.00-13.00 - Cryogenic data collection - Elspeth Garman
13.00-14.00 - Lunch
14.00-15.00 - Crystals and symmetry in real space -Edward Hough
15.00-15.30 - Coffee Break
15.30-16.30 - X-ray Detectors – Christoph Hermes
16.45-18.15 - Tutorial 1 - Cryogenic Data Collection - Elspeth Garman
18.15-19.15 - Poster session

Day 2 - 21 Out 2012 - Sunday
09.00-09.15 - Summary of the previous day
09.15-10.15 - Reciprocal Space and X-ray Scattering - Edward Hough
10.15-10-45 - Coffee Break
10.45-11.45 - Practical Aspects of Crystallographic Data Collection - Elspeth Garman
12.00-13.00 - Data Processing: Integration - Andrew Leslie
13.00-14.00 - Lunch
14.00-15.30 - Tutorial 1 - Integration with MOSFLM - Andrew Leslie
15.30-16.00 - Coffee Break
16.00-17.30 - Tutorial 2 - Scaling With SCALA - Andrew Leslie
17.30-18.45 - Poster session

Day 3 - 22 Out 2012 - Monday
09.00-09.15 - Summary of the previous day
09.15-10.15 - Data Processing: Scaling - Andrew Leslie
10.15-10.45 - Coffee Break
10.45-11.45 - Data Collection. Strategy – Zbigniew Dauter
12.00-13.00 - Patterson Function and Direct Methods - Thomas Schneider
13.00-14.00 - Lunch
14.00-15.30 - Tutorial 1 - Structure Factor Tutorial - Kevin Cowtan
15.30-16.00 - Coffee Break
16.00-17.30 - Tutorial 2 - Management and dissemination of structural data - Isabel Bento
17.45-18.45 - Sample preparation and crystallization of proteins- Rob Meijers

Day 4 - 23 Oct 2012 - Tuesday
09.00-09.15 - Summary of the previous day
09.15-10.15 - Substructures and their Structure Factors -Thomas Schneider
10.15-10-45 - Coffee Break
10.45-11.45 - Density Modification - Kevin Cowtan
12.00-13.00 - Burning Questions - All
13.00-14.00 - Lunch
14.00-15.30 - Tutorial 1 - Substructures 1 - Thomas Schneider
15.30-16.00 - Coffee Break
16.00-17.30 - Tutorial 2 - Pirate and BUCANEER - Kevin Cowtan
17.45-18.45 - IUBMB Lecture | Crystallographic studies of membrane proteins - Challenges and advantages - Poul Nissen

Day 5 - 24 Oct 2012 - Wednesday
09.00-09.15 - Summary of the previous day
09.15-10.15 - Maximum Likelihood - Kevin Cowtan
10.15-10-45 - Coffee Break
10.45-11.45 - Molecular Replacement – Gabor Bunkoczi
12.00-13.00 - SAD Phasing - Zbigniew Dauter
13.00-14.00 - Lunch
Free Afternoon

Day 6 - 25 Oct 2012 - Thursday
10.00-10.15 - Summary of the previous day
10.15-11.15 - The Physics Behind Anomalous Scattering - Gordon Leonard
11.15-11.45 - Coffee Break
11.45-12.45 - Classical MIR Phasing - Clemens Vonrhein
13.00-14.00 - Lunch
14.00-15.30 - How to read and understand the International Tables - Zbigniew Dauter
15.30-16.00 - Coffee Break
16.00-17.30 - Tutorial - MIR structure solution with SHARP - Clemens Vonrhein
17.45-18.45 - Structural Biology with X-ray free electron lasers - Adrian Mancuso

Day 7 - 26 Oct 2012 - Friday
09.00-09.15 - Summary of the previous day
09.15-10.00 - Principles of Automated Model Building and Iterative Refinement - Anastassis Perrakis
10.00-10.30 - Coffee Break
10.30-12.00 - Tutorial - Auto Tracing - Anastassis Perrakis
12.00-13.00 - Model Interpretation - Thomas Schneider
13:00-14:00 – Lunch
14:00-15:00 - Tutorial - Manual Model Building - Bernhard Lohkamp
15:00-15:30 - Coffee Break
15:30-17:00 - Tutorial - Molecular Replacement with PHASER - Gabor Bunkoczi
17:00-18:00 - Burning questions - ALL

Day 8 - 27 Oct 2012 - Saturday
09.00-09.15 - Summary of the previous day
09.15-10.00 - Model Validation - Margarida Archer
10.00-10.30 - Coffee Break
10.30-12.00 - Twinning - Carlos Frazão
12.00-13.30 – Lunch
13.30-15.00 - Manual Model Building and Refinement - Bernhard Lohkamp
15.00-15.30 - Coffee Break
15.30-17.00 - Tutorial - Model Refinement and Completion - Pedro Matias/Célia Romão
 

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