[SCAN] Model-based metabolic engineering - from genome-scale networks to improved microbial cell factories
Isabel Rocha, University of Minho
| When |
12 Apr, 2017
from
12:00 pm to 01:00 pm |
|---|---|
| Where | Auditorium |
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Title: Model-based metabolic engineering - from genome-scale networks to improved microbial cell factories
Speaker: Isabel Rocha
Affiliation: Centre of Biological Engineering, University of Minho, Braga and Protein Modelling Lab - ITQB
Abstract
The field of Metabolic Engineering (ME) has gained a major importance, since it allows the design of improved microorganisms for industrial applications, starting with wild-type strains that usually have low production capabilities in terms of the target compounds. The ultimate aim of ME is to identify genetic manipulations in silico leading to improved microbial strains, that can be implemented using novel molecular biology techniques. This task, however, is a complex one, requiring the existence of reliable metabolic models for strain simulation and robust optimization algorithms for target identification.
In this talk, I will go through the main concepts of genome-scale modelling and the simulation and design of microbial cell factories while describing our group’s main contributions to the
