[Seminar 10h30] Assembly of RNPs and other macro-molecular complexes by R2TP and R2TP-like chaperones
Edouard Bertrand, IGMM, CNRS and Université de Montpellier, France
| When |
28 Nov, 2017
from
10:30 am to 11:00 am |
|---|---|
| Where | Auditorium |
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Seminar
Title: Assembly of RNPs and other macro-molecular complexes by R2TP and R2TP-like chaperones
Speaker: Edouard Bertrand
Affiliation: IGMM, CNRS and Université de Montpellier, France
Abstract:
Many cellular functions are performed by molecular machines composed of stable protein-only or protein-RNA complexes. Understanding how these complexes are produced is a key question in cell biology. Studies with simple RNP particles such as snRNPs/snoRNPs or with more complex ones like the ribosome have highlighted a surprisingly large number of proteins that function in their assembly pathway. In fact, the number of factors involved is so large that it can outnumber the number of proteins forming the final RNP complex. These assembly factors often function as chaperones, escorting the nascent polypeptide to its site of assembly, preventing non-specific interactions and also stimulating assembly with its partners.
The HSP90/R2TP system is a chaperone that functions in the assembly of key cellular RNPs and protein-only complexes, such as snRNPs/snoRNPs, RNA polymerases, and complexes containing PIKKs. The R2TP is a model of choice to study quarternary folding, and I will present our current understanding of its functions.
