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[Seminar] Engineering Biomolecular Affinity

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Roberto Lins, Instituto Aggeu Magalhães, Brazil

When 22 Jun, 2017 from
11:00 am to 12:00 pm
Where Room 2.13
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Title: Engineering Biomolecular Affinity

Speaker: Roberto Lins

Affiliation: Instituto Aggeu Magalhães, Oswaldo Cruz Foundation, Brazil

Host: Prof. Cláudio M. Soares, Protein Modeling



Protein engineering is directed towards finding or tunning properties of a specific system. However, conformational instability of the engineered chimeras often leads to loss of native conformation followed by degradation and/or aggregation, therefore limiting success rate. To overcome this issue, we have devised a protocol that combines de novo and molecular dynamics techniques to address biomolecular affinity in a predictive manner. The talk will showcase examples in how to design antigen-antibody interactions, enzyme catalysis and protein adhesion to cardiac devices and mineral surface.


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