Publications

 Publications

41. Miranda, V.; Maycock, C. D.; Ventura, M. R.. “An efficient stereoselective synthesis of (+)-piscidic acid and cimicifugic acid L”. Eur. J. Org. Chem. 2015, accepted for publication.

40. Maranha, A.; Moynihan, P. J.; Miranda, V.; Lourenço, E. C.; Nunes-Costa, D.; Fraga, J. S.; Pereira, P. J. B.; Macedo-Ribeiro, S.; Ventura, M. R.; Clarke, A. J.; Empadinhas, N. "Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharides", Sci. Rep. 2015, 5, 13610; doi: 10.1038/srep13610 (2015), in press.

39. Vila-Real, H.; Ventura, M. R.; Maycock, C. D.; Iranzo, O.; Simplício, A. L. “An Alternative Synthetic Route to (3R,5S,1′S)-5-{1′-[(tert-Butyloxycarbonyl)amino]-3′-methylbutyl}-3-methyldihydrofuran-2(3H)-one, a Precursor of a Leu-Ala Hydroxyethylene Isostere”, Synthesis 2015, DOI: 10.1055/s-0034-1381036, in press.

38. Real, H. V.; Coelho, H.; Rocha, J.; Fernandes, A.; Ventura, M. R.; Maycock, C. D.; Iranzo, O.; Simplício, A. L. “Peptidomimetic β-secretase inhibitors comprising a sequence of Amyloid-β peptide for Alzheimer's disease”, J. Med. Chem. 2015, 58, 5408.

37. Paixão, L.; Oliveira, J.; Veríssimo, A.; Vinga, S.; Lourenço, E. C.; Ventura, M. R.; Kjos, M. ; Veening, J.-W.; Fernandes, V. E.; Andrew, P. W.; Yesilkaya, H.; Neves, A. R. "Host glycan sugar-specific pathways in Streptococcus pneumoniae: galactose as a key sugar in colonisation and infection", PLoS ONE 2015, 10(3): e0121042. doi:10.1371/journal.pone.0121042. pmid:25826206.

36. Lamosa, P; Lourenço, E. C.; d’Avó, F.; Nobre, A.; Bandeiras, T. M.; S. da Costa, M.; Ventura, M. R.; Santos, H. “A unique glyceryl diglycoside identified in the thermophilic, radiation-resistant bacterium Rubrobacter xylanophilus”, Extremophiles 2015, 19, 373.

35. Pimpão, R. C.; Ventura, M. R.; Ferreira, R. B.; Williamson, G.; Santos, C. N. "Phenolic-sulfates as new and highly abundant metabolites in human plasma after ingestion of a mixed berry fruit puree", British Journal of Nutrition 2015, 113, 454.
34. Alarico, S.; Costa, M.; Sousa, M.; Maranha, A.; Lourenço, E. C.; Faria, T.; Ventura, M. R.; Empadinhas, N. "Mycobacterium hassiacum recovers from nitrogen starvation with up-regulation of a novel glucosylglycerate hydrolase and depletion of the accumulated glucosylglycerate", Scientific Reports 2014, 4, 6766.
33. Marques, J. C.; Oh, I. K.; Ly, D. C.; Lamosa, P.; Ventura, M. R.; Miller, S. T.; Xavier, K. B. “LsrF, a coenzyme A-dependent thiolase, catalyzes the terminal step in processing the quorum sensing signal autoinducer-2”, PNAS 2014, 111, 14235.
32. Maycock, C. D.; Rodrigues, P.; Ventura, M. R. “Use of Aziridines for the Stereocontrolled Synthesis of (−)-LLC10037α, (+)-MT35214, and (+)-4-epi-MT35214”, J. Org. Chem. 2014, 79, 1929.
31. Ventura, M. R. “Asymmetric syntheses based on organocatalysis”, Mini-Reviews in Organic Chemistry 2014, 11, 154.
30. Lourenço, E. C.; Ventura, M. R. “The effect of electron withdrawing protecting groups at positions 4 and 6 on 1,2-cis galactosylation”, Tetrahedron 2013, 69, 7090.
29. Nobre, A.; Empadinhas, N.; Nobre, M. F.; Lourenço, E. C.; Maycock, C.; Ventura, M. R.; Mingote, A.; da Costa, M. S., “The plant Selaginella moellendorffii possesses enzymes for synthesis and hydrolysis of the compatible solutes mannosylglycerate and glucosyslglycerate”, Planta 2013, 237, 891.

28. Lamosa, P.; Rodrigues, M. V.; Gonçalves, L. G.; Carr, J.; Ventura, R.; Maycock, C.; Raven, N. D.; Santos, H. “Organic solutes in the deepest phylogenetic branches of Bacteria: identification of α-(1→6)-glucosyl-α-(1→2)-glucosylglycerate in Persephonella marina”, Extremophiles 2013, 17, 137.

27. Maycock, C. D.; Ventura, M. R. “New organocatalysts derived from tartaric and glyceric acids for direct aldol reactions”, Tetrahedron: Asymmetry 2012, 23, 1262.

26. Rui, F.; Marques, J. C.; Miller, S. T.; Maycock, C. D.; Xavier, K. B.; Ventura, M. R. “Sterochemical diversity of AI-2 analogs modulates quorum sensing in Vibrio Harveyi and Escheria coli”, Bioorg. Med. Chem. 2012, 20, 249.
25. Lourenço, E. C.; Ventura, M. R. “Synthesis of Potassium (2R)-2-O-α-D-Mannopyranosyl-(1→2)-α-Dglucopyranosyl-2,3-dihydroxypropanoate: A Naturally Compatible Solute”, Eur. J. Org. Chem. 2011, 6698.
24. Marques, J. C.; Lamosa, P.; Russell, C.; Ventura, R.; Maycock, C.; Semmelhack, M. F.; Miller, S. T.; Xavier, K. X., “Processing the Interspecies Quorum-sensing Signal Autoinducer-2 (AI-2). Characterization of Phospho-(S)-4,5-dihydroxy-2,3-pentanedione Isomerization by LsrG Protein”, J. Bio. Chem. 2011, 286, 18331.23.
23. Jorge, C. D.; Ventura, R.; Maycock, C.; Outeiro, T. F.; Santos, H.; Costa, J. “Assessment of the Efficacy of Solutes from Extremophiles on Protein Aggregation in Cell Models of Huntington’s and Parkinson’s Diseases”, Neurochem. Res. 2011, 36, 1005.
22. Ascenso, O. S.; Marques, J. C.; Santos, A. R.; Xavier, K. X.; Ventura, M. R.; Maycock, C. D. “An efficient synthesis of the precursor of AI-2, the signalling molecule for inter-species quorum sensing”, Bioorg. Med. Chem. 2011, 19, 1236.
21. Lourenço, E. C.; Ventura, M. R. “The Synthesis of compatible solute analogues – solvent effects on selective glycosylation”, Carbohydrate Research 2011, 346, 163.
20. Lourenço, E. C.; Maycock, C. D.; Ventura, M. R. “Synthesis of potassium (2R)-2-O-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-2,3-dihydroxypropanoate a natural compatible solute”, Carbohydrate Research 2009, 344, 2073.
19. Faria, T.; Mingote, A.; Siopa, F.; Ventura, R.; Maycock, C.; Santos, H. “Design of new enzyme stabilizers inspired by glycosides of hyperthermophilic microorganisms”, Carbohydrate Research 2008, 343, 3025.
18. Rodrigues, M. V.; Borges, N; Henriques, M.; Lamosa, P.; Ventura, R.; Fernandes, C.; Empadinhas, N.; Maycock, C.; Costa, M. S.; Santos, H.; “Bifunctional CTP:Inositol-1-phosphate Cytidylyltransferase/CDP inositol: Inositol-1-phosphate Transferase, The Key Enzyme for Di-Myo-Inositol-Phosphate Synthesis in Several (Hyper)Thermophiles”, Journal of Bacteriology 2007, 189, 15, 5405.
17. Borges, N; Gonçalves, L. G.; Rodrigues, M. V.; Siopa, F.; Ventura, R.; Maycock, C.; Lamosa, P.; Santos, H. “The Byosynthetic Pathways of Inositol and Glycerol Phosphodiesters used by the Hyperthermophile Archaeoglobus Fulgidus in Stress Adaptation” Journal of Bacteriology 2006, 188, 8128.
16. Burke, A. J.; Maycock, C. D.; Ventura, M. R., “Stereoselective Alkylation of Tartrate Derivatives. A Concise Route to (+)-Piscidic Acid and Natural Analogues” Org. Biomol. Chem. 2006, 4, 2361.
15. Ramos, A.; Neves, A. R.; Ventura, R.; Maycock, C.; López, P.; Santos, H. “Effect of Pyruvate Kinase Overproduction in Glucose Metabolism of Lactococcus lactis” Microbiology 2004, 150, 1103.
14. Noronha, M.; Lima, J. C.; Lamosa, P.; Santos, H.; Maycock, C.; Ventura, R.; Maçanita, A. L. “Intramolecular Fluorescence Quenching of Tyrosine by the Peptide α-Carbonyl Group Revisited” J Phys Chem A 2004, 108 (12), 2155.
13. Lamosa, P.; Turner, D. L.; Ventura, R.; Maycock, C.; Santos, H. “Protein Stabilization by Compatible Solutes: Effect of Diglycerol Phosphate on the Dynamics of Desulfovibrio gigas Rubredoxin Studied by NMR” Eur. J. Biochem. 2003, 270, 4606.
12. Barros, M. T.; Maycock, C. D.; Ventura, M. R., “Aziridines as a Protecting and Directing Group. Stereoselective Synthesis of (+)-Bromoxone” Org. Lett. 2003, 5, 4321.
11. Barros, M. T.; Maycock, C. D.; Ventura, M. R., “Aldol Reactions of Dioxanes Derived from Tartatic Acid. A Total Synthesis of (+)-Nephrosteranic Acid” Org. Lett. 2003, 5, 4097.
10. Neves, A. R.; Ventura, R.; Mansour, N.; Shearman, C.; Gasson, M. J.; Maycock, C.; Ramos, A.; Santos, H. “Is the glycolytic flux in Lactococcus lactis primarily controlled by the redox charge? Kinetics of NAD+ and NADH pools determined in vivo by 13C-NMR” J. Bio. Chem. 2002, 277, 28088.
9. Barros, M. T.; Maycock, C. D.; Ventura, M. R., “Stereoselective Radical Reactions of Some Tartaric and Glyceric Acid Derivatives” Org. Lett. 2002, 4, 2035.
8. Barros, M. T.; Maycock, C. D.; Ventura, M. R., “A Synthesis of Aziridines from α-Iodocycloenones” Tetrahedron Lett. 2002, 43, 4329.
7. Barros, M. T.; Maycock, C. D.; Madureira, M. I.; Ventura, M. R., “The Effect of Diethylamine on Stille Alkylations with Tetraalkylstannanes” Chem. Commun. 2001, 1662.
6. Barros, M. T.; Maycock, C. D.; Ventura, M. R., “Approaches to the Synthesis of (+)- and (-)-Epibatidine” J. Chem. Soc. Perkin Trans. I 2001, 166.
5. Barros, M. T.; Maycock, C. D.; Ventura, M. R., “The First Synthesis of (-)-Asperpentyn and Efficient Syntheses of (+)-Harveynone, (+)-Epiepoformin and (-)-Theobroxide” Chem. Eur. J. 2000, 6, 3991.
4. Alves, C.; Barros, M. T.; Maycock, C. D.; Ventura, M. R., “The Synthesis of Shikimic Acid and Derivatives from D-(-)-Quinic Acid” Tetrahedron 1999, 55, 8443.
3. Barros, M. T.; Maycock, C. D.; Ventura, M. R., “The Effect of DMSO on the Borohydride Reduction of a Cyclohexanone: A formal Enantioselective Synthesis of (+)-Epibatidine” Tetrahedron Lett. 1999, 40, 557.
2. Barros, M. T.; Maycock, C. D.; Ventura, M. R., “The Enantioselective Total Synthesis of Epoformin and Analogues” Tetrahedron 1999, 55, 3233.
1. Barros, M. T.; Maycock, C. D.; Ventura, M. R., “Enantioselective Total Synthesis of (+)-Eutypoxide B” J. Org. Chem. 1997, 62, 3984.