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Biomolecular NMR

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Our focus is the application of NMR to various biomolecular problems. We are interested in protein structure determination - dynamics, protein-protein interactions including the study of metalloproteins and large proteins.

 

Manolis Matzapetakis
Investigador Auxiliar
PhD 2004 in Biological Chemistry, University of Michigan, USA

Phone (+351) 214469352 | Extension 1352
matzman@itqb.unl.pt

 

Research Interests

Our focus is the application of NMR to various biomolecular problems. We are interested in protein structure determination - dynamics, protein-protein interactions including the study of metalloproteins and large proteins.

Topics of research include the: 

  • Study or ferrous transport mechanisms in pathogenic bacteria.
    While significant amount of research has been done in the field of  sequestering and transport system of iron we are still discovering new proteins that seem to function as transporters. We are interested in the structural and functional characterization of such proteins with an emphasis in pathogenic bacteria.
  • Development of protocols for NMR based structural proteomics,
    Develop protocols for high throughput use of high field NMR in proteomics. Application of fast NMR acquisition and automated structure determination. Optimization of NMR friendly, high throughput protocols for protein production.
  • In cell protein NMR.
    Use in-cell NMR as a quick way to evaluate protein folding inside the cell.

 

Group Members

 

 

Selected Publications

  1. Bermel, W., I. Bertini, I.C. Felli, M. Matzapetakis, R. Pierattelli, E.C. Theil, P. Turano, A method for C<alpha> direct-detection in protonless NMR. J. Mag.  Res., 2007. 188(2): p. 301-10.
  2. Matzapetakis, M., P. Turano, E.C. Theil,I. Bertini, (13)C- (13)C NOESY spectra of a 480 kDa protein: solution NMR of ferritin. J Biomol NMR, 2007. 38(3): p. 237-42.

 

Laboratory's Website

For further information please visit the laboratory's website

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