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Manuel J.T. Carrondo Lab

Animal Cell Technology Unit

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Our research is centered on integrative development of bioprocesses for complex biopharmaceuticals namely vaccines, recombinant proteins and viral vectors for gene therapy .
 

 

Manuel Carrondo

Manuel J.T. Carrondo
Professor Catedrático, ITQB NOVA/IBET/FCT-UNL
PhD in 1979, Environmental Engineering, Imperial College, London

Phone (+351) 214469362 | Extension 1362
mjtc@itqb.unl.pt

short CV

 

 

Research Interests

Within the Animal Cell Technology unit, the Engineering Cellular Applications laboratory deals with integrating upstream and downstream processes and physico – mathematical tools geared towards applications, in particular for the production of complex and novel biopharmaceuticals. Simplicity, feasibility, transferability and economics are criteria used to design processes that may find industrialization opportunities. Having started with posttranslationally modified protein biopharmaceuticals in the early nineties, such criteria, design and process applications have been extended to vaccines, gene and cell therapy, drawing from the expertise and research achievements of the other labs in the ACTU. Over the last ten years, downstream technologies and modelling towards biological and chemical process control have constituted new thrusts for the lab.

 

Group Members

  • António Roldão PhD, Assistant , Head Vaccine Development
  • Gonçalo Real, PhD, Assistant Researcher, Coordinator of Research Contracts
  • Ana Barbas, PhD, Assistant Researcher, Head Bayer Satellite Lab
  • Inês Isidro, PhD, Pos-Doc, Systems Biotechnology
  • João Vidigal, PhD Student (co-supervision with Ana Teixeira)
  • Sofia Carvalho, PhD Student (co-supervision with Cristina Peixoto)
  • Marcos Sousa, Technician, PhD Student (co-supervision with António Roldão)
  • João Sá, PhD Student (co-supervision with Ana Teixeira)
  • Cristina Peixoto PhD, Head Dowstream
  • Carina Brilha, Technician (Lab Manager)


Selected Publications

  1. Cunha B, Silva RJ, Aguiar T, Serra M, Daicic J, Maloisel JL, Clachan J, Åkerblom A, Carrondo MJ, Peixoto C, Alves PM (2016) “Improving washing strategies of human mesenchymal stem cells using negative mode expanded bed chromatography”, Journal of Chromatography A, 15;1429:292-303.
  2. Nestola P, Peixoto C, Silva RJS, Alves PM, Mota JPB, Carrondo MJT (2015) “Improved virus purification processes for vaccines and gene therapy”, Biotechnology and Bioengineering, 112(5):843-57.
  3. Pais DAM, Carrondo MJT, Alves PM, Teixeira AP (2014) “Towards real-time monitoring of therapeutic protein quality in mammalian cell processes”, Current Opinion in Biotechnology, 30:161–167.
  4. CARINHAS N, OLIVEIRA R, ALVES PM, CARRONDO MJ, TEIXEIRA AP (2012) “Systems biotechnology of animal cells: the road to prediction”. Trends Biotechnol, 30(7):377-85

 

ACT Unit Website

For further information please visit the ACT webpage 

 

Laboratório de Engenharia Celular (PT)

Dentro da Unidade de Tecnologia de Células Animais, o Laboratório de Engenharia Celular dedica-se à integração de processos fermentativos e de extracção-purificação, utilizando ferramentas físico-matemáticas conducentes a aplicações industriais, nomeadamente na obtenção de novos biofármacos. No projecto de processos biocelulares, os critérios de simplicidade, exequibilidade, transferência e economicidade surgem como essenciais para a criação de oportunidades de industrialização. A actividade iniciada no dealbar da década de noventa em proteínas com modificações postranslacionais foi sendo alargada a vacinas e terapias génicas e celulares, baseada na competência e investigação desenvolvida pelos dois outros laboratórios da Unidade de TCA. Nos últimos cinco anos reforçou-se actividade em sistemas de purificação e modelação conduzindo a controle de processo, químico e biológico.

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