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Cláudia Santos lab

Our research is centered on the study of the molecular mechanisms underlying the beneficial effects of food nutrients/bioactives components in Health and Disease.

  

Cláudia Nunes dos Santos
Investigador Auxiliar, IBET
PhD in Biochemistry, 2006, FCUL

Phone (+351) 214469651 | Extension 1651
csantos@itqb.unl.pt


Research Interests

Molecular Nutrition and Health research group interests are grounded on nutritional biochemistry focusing on nutrients/bioactives components and its derivatives, their metabolization,  physiological processes and the molecular mechanisms behind their effects on health and disease. Our approaches combine metabolism and nutritional mechanistic studies in humans, animals and relevant cellular models and organisms. The main cellular pathways associated with proteostasis including autophagy, ubiquitin/proteasome, and the unfolded protein response pathways are the focus. Overall we aim to understand the nutrition-related mechanisms of cellular processes at the molecular level and associated to lifestyle-related chronic illnesses.

 

Group Members

  • Regina Menezes, PhD

  • Paula Pinto, Professor at ESAS

  • Inês Figueira,  PhD student (co-supervised with Catarina Brito, iBET/ITQB NOVA)

  • Andreia Gomes, PhD student

  • Joana Pereira, MSc

  • Filipa Almeida,  MSc (shared with Rita Ventura, ITQB NOVA)

     

Selected Publications

  1. Pimpão RC, Kraut N, Dew T, McDougall GJ, Stewart D, Ferreira RB, Santos CN, Williamson G (2014) Urinary metabolite profiling identifies novel colonic metabolites and conjugates of phenolics in healthy volunteers, Mol Nutr Food Res, 58, 1414-25.

  2. Macedo D, Tavares L,  McDougall GJ, Vicente Miranda H, Stewart D,  Ferreira RB, Tenreiro S,  Outeiro TF, Santos CN (2015) (Poly)phenols protect from alpha-synuclein toxicity by reducing oxidative stress and promoting autophagy. Hum. Mol. Genet. 24(6):1717-32.

  3. Pimpão RC, Ventura V, Ferreira RB, Williamson G, Santos CN, (2015) Phenolic-sulfates as new and highly abundant metabolites in human plasma after ingestion of a mixed berry fruit puree, B J Nutrition, 113, 454-63.

 

Laboratory's Website

For further information please visit the laboratory's website

 

Nutrição Molecular e Saúde (PT)

O laboratório de Nutrição Molecular e Saúde tem como principal interesse entender de que forma os nutrientes/componentes bioativos e seus derivados são metabolizados, assim como os processos fisiológicos e mecanismos moleculares subjacentes aos seus efeitos na saúde e doença.

As nossas abordagens combinam estudos mecanísticos e de metabolismo em humanos, animais e modelo celulares relevantes. O nosso principal foco são as vias celulares associadas com a proteostase,  incluindo autofagia, ubiquitina/proteassoma e as vias de resposta de proteínas “unfolded”. No global nós visamos compreender os processoss celulares relacionados com a nutrição a nível molecular na sáude e nas doenças crónicas relacionadas com o estilo de vida.

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