Books
Protein Folding and Metal Ions: Mechanisms, Biology and Disease
Editor(s): C. M. Gomes and P. Wittung-Stafshede (2010). Taylor & Francis, CRC Press
2010
(#69) Rodrigues, J. V. and Gomes, C.M.
Enhanced superoxide and hydrogen peroxide detection in biological assays
Free Rad Biol Med (2010) in press
(#68) Kim, S., S. S. Leal, B. H. Daniel, C. M. Gomes and S. Lev
Structural requirements for VAP-B oligomerization and their implication in
ALS-associated VAP-B(P56S) neurotoxicity
J Biol Chem (2010) in press
(#67) Correia, A. R., T. Wang, E. A. Craig and C. M. Gomes
Iron-binding activity in yeast frataxin entails a trade off with
stability in the alpha1/beta1 acidic ridge region
Biochem J (2010) 426(2):197-203 
See Commentary by Des Richardson:
(#66) Botelho, HM, Leal, SS, Veith, A, Prosinecki, V, Bauer, C, Frohlich, R, A. Kletzin, C. M. Gomes
Role of a novel disulfide bridge within the all-beta fold of soluble Rieske proteins
J Biol Inorg Chem (2010) 15(2):271-81
2009
(#65) Correia, A.R., Ow, S.Y., Wright, P.C., Gomes, C.M.
The conserved Trp-155 in human frataxin as a hotspot for
oxidative stress
related chemical modifications
Biochem Biophys Res Commun. (2009) 390(3):1007-11
(#64)
Amaral, J.D., Correia, A.R., Steer, C.J., Gomes, C.M., Rodrigues, C.M.P.
No evidence of direct binding between ursodeoxycholic acid and p53 DNA-binding domain
Biosci. Rep. (2009) in press
(#63) Boscolo, B., Leal, S.S., Salgueiro, C.A., Ghibaudi, E., Gomes, C.M.
The prominent conformational plasticity of lactoperoxidase:
a chemical and pH stability analysis
Biochim Biophys Acta - Proteins and Proteomics (2009) 1794(7):1041-8
(#62) Botelho, H., Koch, M., Guenter, F., Gomes, C.M.
Metal ions modulate the folding and stability of the tumor suppressor protein S100A2
FEBS J. (2009) 276(6):1776-86
(#61) Henriques, B.J., Rodrigues, J.V., Olsen, R., Bross, P., Gomes, C.M.
Role of flavinylation in a mild variant of multiple acyl-CoA dehydrogenation deficiency: a molecular rationale for the effects of riboflavin supplementation.
J. Biol. Chem. (2009) 284: 4222-4229
2008
(#60) Faísca, P.F.N. and Gomes, C.M.
On the relation between native geometry and conformational plasticity
Biophysical Chemistry 138(3):99-106
(#59) Selter, M., Melo,A.M.P., Pereira, M.M., Gomes,C.M., Hreggvidsson, G.O., Hjorleifsdottir, S., Saraiva, L.M., Teixeira, M., Archer, M.
A novel type of monoheme cytochrome c: Biochemical and structural characterization at 1.23 Å resolution of Rhodothermus marinus cytochrome c.
Biochemistry (2008) 47(46):11953-63
(#58) Gouveia, R.M., Gomes, C.M., Sousa, M., Alves, P.M., Costa, J.
Kinetic analysis of l1 homophilic interaction: Role of the first four immunoglobulin domains and implications on binding mechanism
J Biol. Chem. (2008) 283(42):28038-47
(#57) Leandro, A., Gomes, C.M.
Protein misfolding in conformational disorders:
rescue of folding defects
and chemical chaperoning
Mini Reviews Medicinal Chemistry (2008) 8(9):901-11
(#56) Correia, A.R., Pastore, C., Adinolfi, S., Pastore, A. Gomes, C.M.
Dynamics, stability and iron-binding activity of frataxin clinical mutants
FEBS J. (2008) 275(14):3680-90
(#55) Leal, S.S., Gomes, C.M. (2008)
On the relative contribution of ionic interactions over iron-sulfur clusters
to ferredoxin stability
Biochim Biophys Acta (2008) 1784(11):1596-600
(#54) Frazão, C. Aragão, D., Coelho, R., Leal, S.S., Gomes, C.M., Teixeira, M., Carrondo, M.A. Crystallographic analysis of the intact metal centres [3Fe4S] and [4Fe4S]
in a Zn(II) containing ferredoxin
FEBS Lett. (2008) 582(5):763-7
2007
(#53) Liz, M.A., Gomes, C.M., Saraiva, M.J., Sousa, M.M.
Apoa-i cleaved by transthyretin has reduced ability to promote cholesterol
efflux and increased amyloidogenicity
J. Lipid Res 48(11):2385-95
(#52) Todorovic, S, Leal, S.S, Salgueiro, CA, Zebger, I, Hildebrandt, P., Murgida, D.H., Gomes, C. M.
A spectroscopic study of the temperature induced modifications on ferredoxin
folding and iron-sulfur moieties
Biochemistry 46(37):10733-8
(#51) Prosinecki, V., Faísca, P.F.N., Gomes, C.M.
Conformational states and protein stability in a proteomic perspective
Current Proteomics (Review) (2007) 4(1), 44-52
(#50) Boscolo, B., Leal, S.S., Ghibaudi, E., Gomes, C.M.
Lactoperoxidase folding and catalysis relies on the stabilization of the alpha-helix
rich core domain: a thermal unfolding study
Biochim Biophys Acta (2007) 1774(9):1164-72
(#49) Leal, S.S. and Gomes, C.M.
Studies of the molten globule state of ferredoxin: structural characterisation and implications on protein folding and iron-sulfur centre assembly
Proteins (2007) 68(3):606-616
2006
(#48) Prosinecki, V., H. M. Botelho, S. Francese, G. Mastrobuoni, G. Moneti, T. Urich, A. Kletzin and C. M. Gomes
A Proteomic Approach toward the Selection of Proteins with Enhanced Intrinsic Conformational Stability
J Proteome Res (2006) 5(10):2720-6
(#47) Rocha, R., S. S. Leal, V. H. Teixeira, M. Regalla, H. Huber, A. M. Baptista, C. M. Soares and C. M. Gomes
Natural domain design: enhanced thermal stability of a zinc-lacking ferredoxin isoform shows that a hydrophobic core efficiently replaces the structural metal site
Biochemistry (2006) 45(34):10376-84
(#46) Correia, A. R., S. Adinolfi, A. Pastore and C. M. Gomes
Conformational stability of human frataxin and effect of Friedreich's ataxia-related mutations on protein folding
Biochem J (2006) 398(3):605-11
(#45) Urich, T., C. M. Gomes, A. Kletzin and C. Frazao
X-ray Structure of a self-compartmentalizing sulfur cycle metalloenzyme
Science (2006) 311(5763):996-1000
(#44) Henriques, B. J., L. M. Saraiva and C. M. Gomes
Combined spectroscopic and calorimetric characterisation of rubredoxin reversible thermal transition
J Biol Inorg Chem (2006) 11(1):73-81
2005
(#43) Leal, S. S. and C. M. Gomes
Linear three-iron centres are unlikely cluster degradation intermediates during unfolding of iron-sulfur proteins
Biol Chem (2005) 386(12):1295-300
(#42) Henriques, B. J., L. M. Saraiva and C. M. Gomes
Probing the mechanism of rubredoxin thermal unfolding in the absence of salt bridges by temperature jump experiments
Biochem Biophys Res Commun (2005) 333(3):839-44
(#41) Kletzin, A., A. S. Ferreira, T. Hechler, T. M. Bandeiras, M. Teixeira and C. M. Gomes
A Rieske ferredoxin typifying a subtype within Rieske proteins: spectroscopic, biochemical and stability studies
FEBS Lett (2005) 579(5):1020-6
2004
(#40) Leal, S. S., M. Teixeira and C. M. Gomes
Studies on the degradation pathway of iron-sulfur centers during unfolding of a hyperstable ferredoxin: cluster dissociation, iron release and protein stability
J Biol Inorg Chem (2004) 9(8):987-96
(#39) Muller, F. H., T. M. Bandeiras, T. Urich, M. Teixeira, C. M. Gomes and A. Kletzin
Coupling of the pathway of sulphur oxidation to dioxygen reduction: characterization of a novel membrane-bound thiosulphate:quinone oxidoreductase
Mol Microbiol (2004) 53(4):1147-60
(#38) Urich, T., T. M. Bandeiras, S. S. Leal, R. Rachel, T. Albrecht, P. Zimmermann, C. Scholz, M. Teixeira, C. M. Gomes and A. Kletzin
The sulphur oxygenase reductase from Acidianus ambivalens is a multimeric protein containing a low-potential mononuclear non-haem iron centre
Biochem J (2004) 381(Pt 1):137-46
(#37) Kletzin, A., T. Urich, F. Muller, T. M. Bandeiras and C. M. Gomes
Dissimilatory oxidation and reduction of elemental sulfur in thermophilic archaea
J Bioenerg Biomembr (2004) 36(1):77-91
(#36) Das, T. K., C. M. Gomes, T. M. Bandeiras, M. M. Pereira, M. Teixeira and D. L. Rousseau
Active site structure of the aa3 quinol oxidase of Acidianus ambivalens
Biochim Biophys Acta (2004) 1655(1-3):306-20
2003
(#35) Victor, B. L., J. B. Vicente, R. Rodrigues, S. Oliveira, C. Rodrigues-Pousada, C. Frazao, C. M. Gomes, M. Teixeira and C. M. Soares
Docking and electron transfer studies between rubredoxin and rubredoxin:oxygen oxidoreductase
J Biol Inorg Chem (2003) 8(4):475-88
(#34) Hellwig, P., C. M. Gomes and M. Teixeira
FTIR spectroscopic characterization of the cytochrome aa3 from Acidianus ambivalens: evidence for the involvement of acidic residues in redox coupled proton translocation
Biochemistry (2003) 42(20):6179-84
(#33) Bandeiras, T. M., C. A. Salgueiro, H. Huber, C. M. Gomes and M. Teixeira
The respiratory chain of the thermophilic archaeon Sulfolobus metallicus: studies on the type-II NADH dehydrogenase
Biochim Biophys Acta (2003) 1557(1-3):13-9
2002
(#32) Bandeiras, T. M., C. Salgueiro, A. Kletzin, C. M. Gomes and M. Teixeira
Acidianus ambivalens type-II NADH dehydrogenase: genetic characterisation and identification of the flavin moiety as FMN
FEBS Lett (2002) 531(2):273-7
(#31) Gomes, C. M., A. Giuffre, E. Forte, J. B. Vicente, L. M. Saraiva, M. Brunori and M. Teixeira
A novel type of nitric-oxide reductase. Escherichia coli flavorubredoxin
J Biol Chem (2002) 277(28):25273-6
(#30) Vicente, J. B., C. M. Gomes, A. Wasserfallen and M. Teixeira
Module fusion in an A-type flavoprotein from the cyanobacterium Synechocystis condenses a multiple-component pathway in a single polypeptide chain
Biochem Biophys Res Commun (2002) 294(1):82-7
(#29) Pereira, M. M., C. M. Gomes and M. Teixeira
Plasticity of proton pathways in haem-copper oxygen reductases
FEBS Lett (2002) 522(1-3):14-8
(#28) Gomes, C. M., C. Frazao, A. V. Xavier, J. Legall and M. Teixeira
Functional control of the binuclear metal site in the metallo-beta-lactamase-like fold by subtle amino acid replacements
Protein Sci (2002) 11(3):707-12
(#27) Gomes, C. M., A. Kletzin and M. Teixeira
An archaeal b-type cytochrome containing a nonfunctional carbonic anhydrase-like domain
J Biol Inorg Chem (2002) 7(4-5):483-9
(#26) Lemos, R. S., A. S. Fernandes, M. M. Pereira, C. M. Gomes and M. Teixeira
Quinol:fumarate oxidoreductases and succinate:quinone oxidoreductases: phylogenetic relationships, metal centres and membrane attachment
Biochim Biophys Acta (2002) 1553(1-2):158-70
(#25) Jones, K., C. M. Gomes, H. Huber, M. Teixeira and P. Wittung-Stafshede
Formation of a linear [3Fe-4S] cluster in a seven-iron ferredoxin triggered by polypeptide unfolding
J Biol Inorg Chem (2002) 7(4-5):357-62
(#24) Lemos, R. S., C. M. Gomes, J. LeGall, A. V. Xavier and M. Teixeira
The quinol:fumarate oxidoreductase from the sulphate reducing bacterium Desulfovibrio gigas: spectroscopic and redox studies
J Bioenerg Biomembr (2002) 34(1):21-30
2001
(#23) Moczygemba, C., J. Guidry, K. L. Jones, C. M. Gomes, M. Teixeira and P. Wittung-Stafshede
High stability of a ferredoxin from the hyperthermophilic archaeon A. ambivalens: involvement of electrostatic interactions and cofactors
Protein Sci (2001) 10(8):1539-48
(#22) Lemos, R. S., C. M. Gomes, M. Santana, J. LeGall, A. V. Xavier and M. Teixeira
The 'strict' anaerobe Desulfovibrio gigas contains a membrane-bound oxygen-reducing respiratory chain
FEBS Lett (2001) 496(1):40-3
(#21) Gomes, C. M., J. Le Gall, A. V. Xavier and M. Teixeira
Could a diiron-containing four-helix-bundle protein have been a primitive oxygen reductase?
Chembiochem (2001) 2(7-8):583-7
(#20) Gomes, C. M., C. Backgren, M. Teixeira, A. Puustinen, M. L. Verkhovskaya, M. Wikstrom and M. I. Verkhovsky
Heme-copper oxidases with modified D- and K-pathways are yet efficient proton pumps
FEBS Lett (2001) 497(2-3):159-64
(#19) Lemos, R. S., C. M. Gomes and M. Teixeira
Acidianus ambivalens Complex II typifies a novel family of succinate dehydrogenases
Biochem Biophys Res Commun (2001) 281(1):141-50
(#18) Gomes, C. M., T. M. Bandeiras and M. Teixeira
A new type-II NADH dehydrogenase from the archaeon Acidianus ambivalens: characterization and in vitro reconstitution of the respiratory chain
J Bioenerg Biomembr (2001) 33(1):1-8
(#17) Gilderson, G., A. Aagaard, C. M. Gomes, P. Adelroth, M. Teixeira and P. Brzezinski
Kinetics of electron and proton transfer during O(2) reduction in cytochrome aa(3) from A. ambivalens: an enzyme lacking Glu(I-286)
Biochim Biophys Acta (2001) 1503(3):261-70
2000
(#16) Gomes, C. M., J. B. Vicente, A. Wasserfallen and M. Teixeira
Spectroscopic studies and characterization of a novel electron-transfer chain from Escherichia coli involving a flavorubredoxin and its flavoprotein reductase partner
Biochemistry (2000) 39(51):16230-7
(#15) Frazao, C., G. Silva, C. M. Gomes, P. Matias, R. Coelho, L. Sieker, S. Macedo, M. Y. Liu, S. Oliveira, M. Teixeira, A. V. Xavier, C. Rodrigues-Pousada, M. A. Carrondo and J. Le Gall
Structure of a dioxygen reduction enzyme from Desulfovibrio gigas
Nat Struct Biol (2000) 7(11):1041-5
(#14) Wittung-Stafshede, P., C. M. Gomes and M. Teixeira
Stability and folding of the ferredoxin from the hyperthermophilic archaeon Acidianus ambivalens
J Inorg Biochem (2000) 78(1):35-41
1999
(#13) Das, T. K., C. M. Gomes, M. Teixeira and D. L. Rousseau
Redox-linked transient deprotonation at the binuclear site in the aa(3)-type quinol oxidase from Acidianus ambivalens: implications for proton translocation
Proc Natl Acad Sci U S A (1999) 96(17):9591-6
(#12) Aagaard, A., G. Gilderson, C. M. Gomes, M. Teixeira and P. Brzezinski
Dynamics of the binuclear center of the quinol oxidase from Acidianus ambivalens
Biochemistry (1999) 38(31):10032-41
(#11) Gomes, C. M., R. S. Lemos, M. Teixeira, A. Kletzin, H. Huber, K. O. Stetter, G. Schafer and S. Anemuller
The unusual iron sulfur composition of the Acidianus ambivalens succinate dehydrogenase complex
Biochim Biophys Acta (1999) 1411(1):134-41
(#10) Romao, C. V., M. Y. Liu, J. Le Gall, C. M. Gomes, V. Braga, I. Pacheco, A. V. Xavier and M. Teixeira
The superoxide dismutase activity of desulfoferrodoxin from Desulfovibrio desulfuricans ATCC 27774
Eur J Biochem (1999) 261(2):438-43
(#9) Silva, G., S. Oliveira, C. M. Gomes, I. Pacheco, M. Y. Liu, A. V. Xavier, M. Teixeira, J. Legall and C. Rodrigues-pousada
Desulfovibrio gigas neelaredoxin. A novel superoxide dismutase integrated in a putative oxygen sensory operon of an anaerobe
Eur J Biochem (1999) 259(1-2):235-43
1998
(#8) Gomes, C. M., A. Faria, J. C. Carita, J. Mendes, M. Regalla, P. Chicau, H. Huber, K. O. Stetter and M. Teixeira
Di-cluster, seven-iron ferredoxins from hyperthermophilic Sulfolobales
Journal of Biological Inorganic Chemistry (1998) 3(5):499-507
(#7) Gomes, C. M., H. Huber, K. O. Stetter and M. Teixeira
Evidence for a novel type of iron cluster in the respiratory chain of the archaeon Sulfolobus metallicus
FEBS Lett (1998) 432(3):99-102
(#6) Gomes, C. M. and M. Teixeira
Ambineela, an unusual blue protein isolated from the archaeon Acidianus ambivalens
Biochem Biophys Res Commun (1998) 249(1):23-5
(#5) LeGall, J., M. Y. Liu, C. M. Gomes, V. Braga, I. Pacheco, M. Regalla, A. V. Xavier and M. Teixeira
Characterisation of a new rubredoxin isolated from Desulfovibrio desulfuricans 27774: definition of a new family of rubredoxins
FEBS Lett (1998) 429(3):295-8
(#4) Gomes, C. M. and M. Teixeira
The NADH oxidase from the thermoacidophilic archaea Acidianus ambivalens: isolation and physicochemical characterisation
Biochem Biophys Res Commun (1998) 243(2):412-5
1997
(#3) Giuffre, A., C. M. Gomes, G. Antonini, E. D'Itri, M. Teixeira and M. Brunori
Functional properties of the quinol oxidase from Acidianus ambivalens and the possible catalytic role of its electron donor--studies on the membrane-integrated and purified enzyme
Eur J Biochem (1997) 250(2):383-8
(#2) Gomes, C. M., G. Silva, S. Oliveira, J. LeGall, M. Y. Liu, A. V. Xavier, C. Rodrigues-Pousada and M. Teixeira
Studies on the redox centers of the terminal oxidase from Desulfovibrio gigas and evidence for its interaction with rubredoxin
J Biol Chem (1997) 272(36):22502-8
1996
(#1) Teixeira, M., R. Batista, A. P. Campos, C. Gomes, J. Mendes, I. Pacheco, S. Anemuller and W. R. Hagen
A seven-iron ferredoxin from the thermoacidophilic archaeon Desulfurolobus ambivalens
Eur J Biochem (1995) 227(1-2):322-7