Our research is mostly translational, focused on the study of the cellular interactions occurring within the innate immune microenvironment during disease progression and governing response to advanced therapies. To address these questions, we develop and employ cell-based disease models, using stem cells and other patient-derived cells and exploring three-dimensional culture strategies, along with cell biology and omics approaches. We aim to identify potential predictive biomarkers and microenvironment-related therapeutic targets for several neurological disorders and solid tumors.