Research in our group is centred in the synthesis of biologically relevant N-heterocyclic carbenes (NHCs), and on their applications as ligands to stabilize metallodrugs and catalysts. N-heterocyclic carbenes are extremely versatile ligands, as their electronic and steric characteristics can be easily modulated, reason for which they are widely explored in catalysis.
N-Heterocyclic carbenes can also be formed in biologically relevant molecules, such as nucleobases, and have been reported as active intermediates in DNA damage. However, their formation is poorly understood.
The main work developed by our group is focused on the use of biologically relevant heterocycles such as nucleobases to build novel N-heterocyclic carbenes, as a tool to
- Develop new anticancer-agents.
- Develop new antifungal agents bearing 1,2,3 triazoles
- Develop bi-functional catalytic systems
- Develop novel tools to understand the reactivity of DNA methylation products
Research in our group is centred in the synthesis of biologically relevant N-heterocyclic carbenes (NHCs), and on their applications as ligands to stabilize metallodrugs and catalysts. N-heterocyclic carbenes are extremely versatile ligands, as their electronic and steric characteristics can be easily modulated, reason for which they are widely explored in catalysis.
N-Heterocyclic carbenes can also be formed in biologically relevant molecules, such as nucleobases, and have been reported as active intermediates in DNA damage. However, their formation is poorly understood.
The main work developed by our group is focused on the use of biologically relevant heterocycles such as nucleobases to build novel N-heterocyclic carbenes, as a tool to
- Develop new anticancer-agents.
- Develop new antifungal agents bearing 1,2,3 triazoles
- Develop bi-functional catalytic systems
- Develop novel tools to understand the reactivity of DNA methylation products
