{"id":674,"date":"2025-05-12T16:02:51","date_gmt":"2025-05-12T15:02:51","guid":{"rendered":"https:\/\/www.itqb.unl.pt\/?post_type=evento&#038;p=674"},"modified":"2025-05-12T16:08:25","modified_gmt":"2025-05-12T15:08:25","slug":"scan-disorder-at-the-host-pathogen-interface","status":"publish","type":"evento","link":"https:\/\/www.itqb.unl.pt\/pt-pt\/evento\/scan-disorder-at-the-host-pathogen-interface\/","title":{"rendered":"[SCAN] DiSORDER at the Host-Pathogen Interface"},"content":{"rendered":"<p><strong>Speaker: <\/strong>Tiago Cordeiro<\/p>\n<p><strong>From: <\/strong><a href=\"https:\/\/www.itqb.unl.pt\/research\/biological-chemistry\/dynamic-structural-biology\">Dynamic Structural Biology Lab<\/a><\/p>\n<p><strong>Abstract:\u00a0<\/strong>Intrinsically disordered proteins (IDPs) play emerging roles in infection biology by leveraging structural flexibility to mediate dynamic interactions. In this talk, I will present our recent work on two disordered hubs central to viral and bacterial pathogenesis: the<\/p>\n<p>SARS-CoV-2 nucleocapsid (N) protein and the E. coli effector Tir. Using integrative biophysical methods, we reveal how a conserved coiled-coil motif in the disordered linker of N drives oligomerization and phase separation, offering a detailed ensemble model of its self-assembly. In parallel, we show how Tir exploits disorder to mimic host receptors and modulate signaling through phosphorylation-regulated motifs and membrane interactions. These studies highlight the functional power of disorder at the host-pathogen interface.<\/p>\n<p>SCANs are weekly seminars that happen every Wednesday at noon by in-house researchers and invited speakers at ITQB NOVA.<\/p>\n<p>&nbsp;<\/p>\n<p><span id=\"parent-fieldname-startDate\" class=\" summary\" title=\"12:00 pm\">12:00 pm <\/span> to <span id=\"parent-fieldname-endDate\" class=\" summary\" title=\"01:00 pm\"> 01:00 pm <\/span><\/p>\n<table class=\"vertical listing\" summary=\"Event details\">\n<tbody>\n<tr>\n<th>Contact Name<\/th>\n<td class=\"fn\"><span id=\"parent-fieldname-contactName-22f20c4a4ac548ff9b528e7de8fcb5ac\" class=\"\"> Sandra Viegas <\/span><\/td>\n<\/tr>\n<tr>\n<th>Contact Email<\/th>\n<td class=\"email\"><a id=\"parent-fieldname-contactEmail\"><\/a><a href=\"mailto:sviegas@itqb.unl.pt\">sviegas@itqb.unl.pt<\/a><\/td>\n<\/tr>\n<tr>\n<th>Add event to your calendar<\/th>\n<td><a title=\"Download this event in iCal format\" href=\"https:\/\/www.itqb.unl.pt\/events\/seminars\/scan-tiago-cordeiro-2\/ics_view\"> <img loading=\"lazy\" decoding=\"async\" title=\"iCal export\" src=\"https:\/\/www.itqb.unl.pt\/icon_export_ical.png\" alt=\"\" width=\"16\" height=\"16\" \/> iCal<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Speaker: Tiago Cordeiro From: Dynamic Structural Biology Lab Abstract:\u00a0Intrinsically disordered proteins (IDPs) play emerging roles in infection biology by leveraging structural flexibility to mediate dynamic interactions. In this talk, I will present our recent work on two disordered hubs central to viral and bacterial pathogenesis: the SARS-CoV-2 nucleocapsid (N) protein and the E. coli effector [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":231,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"tags":[15],"class_list":["post-674","evento","type-evento","status-publish","has-post-thumbnail","hentry","tag-seminars"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.itqb.unl.pt\/pt-pt\/wp-json\/wp\/v2\/evento\/674","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.itqb.unl.pt\/pt-pt\/wp-json\/wp\/v2\/evento"}],"about":[{"href":"https:\/\/www.itqb.unl.pt\/pt-pt\/wp-json\/wp\/v2\/types\/evento"}],"author":[{"embeddable":true,"href":"https:\/\/www.itqb.unl.pt\/pt-pt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.itqb.unl.pt\/pt-pt\/wp-json\/wp\/v2\/comments?post=674"}],"version-history":[{"count":1,"href":"https:\/\/www.itqb.unl.pt\/pt-pt\/wp-json\/wp\/v2\/evento\/674\/revisions"}],"predecessor-version":[{"id":675,"href":"https:\/\/www.itqb.unl.pt\/pt-pt\/wp-json\/wp\/v2\/evento\/674\/revisions\/675"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.itqb.unl.pt\/pt-pt\/wp-json\/wp\/v2\/media\/231"}],"wp:attachment":[{"href":"https:\/\/www.itqb.unl.pt\/pt-pt\/wp-json\/wp\/v2\/media?parent=674"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.itqb.unl.pt\/pt-pt\/wp-json\/wp\/v2\/tags?post=674"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}