Unravelling the way to antimicrobial activity through a systematic validation of natural-based lipid nanocarriers approach
Duration: minimum 12 weeks full time
The skin provides a critical barrier against bacterial infections. Topical antimicrobial treatments are commonly used to treat skin infections. They provide antimicrobial activity specifically against the causative agent, a high and continued drug concentration at the infected site, they have fewer systemic side effects
and reduce the development of antibiotic resistance. Nanostructured lipid carriers (NLCs) have gained significant attention as safe and biodegradable systems for the dermal drug delivery due to their stability, biocompatibility, and ability to improve drug bioavailability. The aim in this project is to characterize the most promising NLCs, to evaluate these systems for their ability to permeate the skin, both in vitro and in vivo; to understand the molecular mechanisms of NlCs permeation through human skin; and to investigate their antimicrobial capacity in vitro and in vivo.