Herpesvirus LANA interaction with USP7 and Elongin BC
Duration: 6 weeks (Bachelor’s thesis)
BACKGROUND
The Latency-Associated Nuclear Antigen (LANA) is a herpesvirus multifunctional protein responsible for tethering the viral DNA to the chromosome, ensuring maintenance and segregation of the viral genome during cell division. Besides its main role in viral maintenance, LANA also physically interacts with several host proteins (USP7 & Elongin BC) to modulate cell functions to maintain viral latency.
OBJECTIVES
The project will focus on assessing the relationship between USP7 and Elongin BC on binding to LANA, from both KSHV and MHV-68 herpesviruses, using various biophysical techniques.