[Seminar] Understanding thiol redox signaling through computational modeling and systems analysis
Armindo J. Salvador, Centre for Neuroscience and Cell Biology, The University of Coimbra
| When |
10 Feb, 2017
from
02:00 pm to 03:30 pm |
|---|---|
| Where | Auditorium |
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Seminar
Title: Understanding thiol redox signaling through computational modeling and systems analysis
Speaker: Armindo J. Salvador
Affiliation: Head of the Computational & Systems Biology Group, Centre for Neuroscience and Cell Biology, The University of Coimbra
Host: Claudine Chaouiya and Isabel Rocha (MolBioS PhD Program)
Abstract:
Hydrogen peroxide (H2O2) is a key signaling agent in cell proliferation, chemotaxis, wound healing and vascular adaptation, but the mechanisms whereby it exerts its regulatory actions remain unclear. Puzzlingly, known redox-regulated proteins are too poorly H2O2-reactive to respond to stimuli in the observed signaling time frame. Our quantitative mathematical modeling and systems analyses demonstrate that several current hypotheses to explain this conundrum are inconsistent with the known properties of key thiol redox proteins, prompt an alternative hypothesis and permit deriving design principles for effective redox signalling.
