The story of Hunchback and the dwarf
Thomas Edwards, University of Leeds
| When |
13 Jan, 2010
from
03:00 pm to 04:00 pm |
|---|---|
| Where | Room 2.13 |
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Seminar
Title: The story of Hunchback and the dwarf
Speaker: Thomas Edwards
Affiliation: Institute of Molecular and Cell Biology,University of Leeds
Abstract
Control of eukaryotic gene expression at the translation level is vital for many important physiological processes. This control is mediated by hundreds of cytoplasmic RNA binding proteins (RBPs) that regulate the processing, localisation, translation and decay of mRNA. One well characterised example of the importance of translational control by RBPs occurs in Drosophila where repression of translation of localised maternal mRNA is required for anterior/posterior patterning during early embryogenesis. Pumilio binds to a pair of specific sequences termed the Nanos response elements (NREs) in the 3'-UTR of hunchback (hb) mRNAs and represses translation through recruitment of Nanos and Brain Tumor (Brat) proteins. A history of the structural biology of Pumilio will be presented.
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