[SCAN] Manipulation of host cells by Chlamydia trachomatis
Jaime Mota
| When |
09 Sep, 2020
from
12:00 pm to 01:00 pm |
|---|---|
| Contact Name | Rita Abranches |
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Speaker: Jaime Mota
Affiliation: Alumnus ITQB NOVA; FCT NOVA
Title: Manipulation of host cells by Chlamydia trachomatis
Abstract:
Chlamydia trachomatis is an obligate intracellular bacterial pathogen, mainly causing ocular and urogenital infections that affect millions of people worldwide and which can lead to blindness or sterility. C. trachomatis reside and multiply intracellularly within a membrane-bound vacuolar compartment, known as inclusion. In this compartment, Chlamydia undergoes a developmental cycle involving two morphologically and physiologically distinct forms. Completion of this cycle involves the secretion of > 70 Chlamydia proteins that function in the host cell cytoplasm and nucleus, in the inclusion membrane and lumen, and in the extracellular milieu. Our work is focused on the identification and characterization of these secreted proteins. In this seminar, I will summarize our ongoing studies on chlamydial secreted proteins that manipulate host cell division, associate with host cell lipid storage organelles, and promote the lytic escape of Chlamydia from infected host cells.
Zoom webinar - ITQB NOVA Virtual Auditorium
