Publications

Publications within refereed international journals

14. J.A. Brito, N. Borges, C. Vonrheinb, H. Santos, M. Archer (2011) Crystal structure of Archaeoglobus fulgidus CTP:inositol-1-phosphate cytidyltransferase, a key enzyme for di-myo-inositol-phosphate synthesis in (hyper)thermophiles. J. Bacterial. 193:2177-85.

13. S. Gonçalves, A. Esteves, N. Borges, H. Santos, P.M. Matias (2011) Crystallization and preliminary X-ray analysis of mannosyl-3-phosphoglycerate phosphatase from Thermus thermophilus HB27. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 67:390-6.

12. J.A. Brito, N. Borges, H. Santos, M. Archer (2010) Production, crystallization and preliminary X-ray analysis of CTP:inositol-1-phosphate cytidyltransferase from Archaeoglobus fulgidus. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66:1463–5.

11. S. Gonçalves, N. Borges, A.M. Esteves, B.L. Victor, C.M. Soares, H. Santos, P.M. Matias (2010) Structural analysis of Thermus thermophilus HB27 mannosyl-3-phosphoglycerate synthase provides evidence for a second catalytic metal ion and new insight into the retaining mechanism of glycosyltransferases. J. Biol. Chem. 285:17857-68.

10. N. Borges, R. Matsumi, T. Imanaka, H. Atomi and H. Santos (2010) Thermococcus kodakaraensis mutants deficient in di-myo-inositol phosphate use aspartate to cope with heat stress. J. Bacteriol. 192:191-7.

9. S. Gonçalves, N. Borges, H. Santos, P.M. Matias (2009) Crystallization and preliminary X-ray analysis of mannosyl-3-phosphoglycerate synthase from Thermus thermophilus HB27. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65:1014-7.

8. M.V. Rodrigues, N. Borges, C.P. Almeida, P. Lamosa, H. Santos (2009) A unique β-1,2-mannosyltransferase of Thermotoga maritima that uses di-myo-inositol phosphate as the mannosyl acceptor. J. Bacteriol. 191:6105-15.

7. F.S. Cardoso, R.F. Castro, N. Borges, H. Santos (2007) Biochemical and genetic characterization of the pathways for trehalose metabolism in Propionibacterium freudenreichii and their role in stress response. Microbiology-SGM. 153:271-81.

6. N. Borges, L.G. Gafeira, M.V. Rodrigues, R. Ventura, C. Maycock, P. Lamosa, H. Santos (2006) Biosynthetic pathways of inositol and glycerol phosphodiesters used for stress adaptation in Archaeoglobus fulgidus. J. Bacteriol. 188:8128-35.

5. N. Borges, J.D. Marugg, N. Empadinhas, M.S. da Costa, H. Santos (2004) Specialized roles of the two pathways for the synthesis of mannosylglycerate in osmoadaptation and thermoadaptation of Rhodothermus marinus. J. Biol. Chem. 279:9892-8.

4. N. Borges, A. Ramos, N.D. Raven, R.J. Sharp, H. Santos (2002) Comparative study of the thermostabilizing properties of mannosylglycerate and other compatible solutes on model enzymes. Extremophiles 6:209-16.

3. N. Empadinhas, J.D. Marugg, N. Borges, H. Santos, M.S. da Costa (2001) Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii: Biochemical and genetic characterization of key enzymes. J. Biol. Chem. 276:43580-8.

2. D. Cánovas*, N. Borges*, C. Vargas, A. Ventosa, J.J. Nieto, H. Santos (1999) Role of N-gamma acetyldiaminobutyrate as enzyme stabilizer and intermediate in the biosynthesis of hydroxyectoine. Appl. Environm. Microbiol. 65:3774-9.*Equal contribution.

1. N. Borges*, Z. Silva*, L.O. Martins, R. Wait, M.S. da Costa, H. Santos (1999) Combined effect of the growth temperature and salinity of medium on the accumulation of compatible solutes by Rhodothermus marinus and Rhodothermus obamensis. Extremophiles. 3:63-172. *Equal contribution. 

Book chapters

3. H. Santos, P. Lamosa, N. Borges, L. G. Gonçalves, T. M. Pais & M. V. Rodrigues (2011) Organic compatible solutes of prokaryotes that thrive in hot environments: the importance of ionic compounds for thermostabilization. In Extremophiles Handbook.  K. Horikoshi, G. Antranikian, A. T. Bull, F. T. Robb, K. O. Stetter (Eds.), Part 4, pp. 497-520, Springer, Tokyo, 2011.

2. H. Santos, P. Lamosa, T.Q. Faria, N. Borges, C. Neves (2007) The physiological role, biosynthesis and mode of action of compatible solutes from (hyper)thermophiles. In Physiology and biochemistry of extremophiles. 86-104. C. Gerday & N. Glandorff (Eds.), 86-104, ASM publishers, Washington, D. C.

1. H. Santos, P. Lamosa, N. Borges (2006) Characterization and quantification of compatible solutes in (hyper)thermophilic microorganisms. In Methods in Microbiology: Extremophiles. A. Oren & F. Rainey (Eds.) 35:173-99, Elsevier Publisher.

Prizes

2007. “Prémio Câmara Pestana 2007” for the work:
“Biosynthetic pathways of inositol and glycerol phosphodiesters used by the hyperthermophile Archaeoglobus fulgidus in stress adaptation”
N. Borges, M. Rodrigues, L. Gafeira, F. Siopa, R. Ventura, C. Maycock, P. Lamosa & H. Santos