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Margarida Saramago

Cerca de 2000 pessoas visitaram a Noite Europeia dos Investigadores na Marina de Oeiras, a 26 de setembro. O evento, organizado pelo ITQB NOVA em parceria com o Município de Oeiras, reuniu mais de 35 instituições científicas, incluindo 9 clubes de ciência.

One single aminoacid change in RNase II drastically improves its catalysis

Maria do Carmo Basílio, Physiology of Environmentally Conditioned Microbiota Lab.

A few tips for hosting a seminar at ITQB NOVA

"How can we improve Oeiras through science?" - 1st Ideas Competition, an initiative promoted by Oeiras Municipality, ITQB NOVA, and IGC, has received several contributions from society on new approaches that can bring science and citizens closer together.

David Cope, Foundation Fellow of Clare Hall, University of Cambridge, UK

Manuela Costa

PUBLICATIONS and PATENTS 20- Yann Astier, Denis E. Kainov, Hagan Bayley, Roman Tuma, Stefan Howorka,”Stochastic Detection of Motor Protein-RNA Complexes by single channel current recording” Chem. Phys Chem. 2007, 8, 2189 – 2194. 19- Haichen Wu, Yann Astier, Giovanni Maglia, Ellina Mikhailova and Hagan Bayley “a-Hemolysin pores with covalently attached molecular adapters” J. Am. Chem. Soc.( 2007), 129 (51), 16142-16148. 18- Hugh Martin,†,§ Helen Kinns,†,§ Nick Mitchell,† Yann Astier,‡ Hagan Bayley,‡ Stefan Howorka†, “Nanoscale protein pores modified with PAMAM dendrimers” J. Am. Chem. Soc.( 2007), 129 (31), 9640 -9649 17- A 'pore' man's sequencing solution? Michael Eisenstein, Nature Methods, Research Highlights, 3, 157 (2006). Covering Astier et al. J. Am. Chem. Soc. (2006), 128(5) 1705-1710 16- Yann Astier, Orit Braha, Hagan Bayley, “Towards single molecule DNA sequencing: direct identification of 5’ monophosphate ribo and deoxy-ribo nucleotides with a protein nanopore equipped with a molecular adapter.” J. Am. Chem. Soc. (2006), 128(5) 1705-1710 15- Yann Astier, Hagan Bayley, Stefan Howorka, “Protein components for nanodevices” Curr Opin Chem Biol 2005, 9:576-584. 14- Yann Astier, Gerard W. Canters, Jason J. Davis, H. Allen O. Hill, Martin P. Verbeet, Hein J. Wijma, “Sensing nitrite through a pseudoazurin-nitrite reductase electron transfer relay “ Chem. Phys. Chem. 2005, 6, 1114-1120. 13- Y. Astier*, A. Bond, H. Wijma, G. W. Canters, H. A. O. Hill, J. J. Davis. A systematic study of the influence of peptide modification of a gold electrode on the electrochemistry of pseudoazurin. Electroanalysis (2004), 16(13-14), 1155-1165. (*corresponding author) 12- Y. Astier, P. N. Bartlett, “The measurement of alkaline phosphatase at nanomolar concentration within 70 s using a disposable microelectrochemical transistor.” Bioelectrochemistry (2004), 64(1), 53-59. 11- Y. Astier, P. N. Bartlett. The demonstration of an enhanced microelectrochemical transistor for measurements in neutral solution at low analyte concentration. Bioelectrochemistry (2004), 64(1), 15-22. 10- L. Andolfi, D. Bruce, S. Cannistraro, G.W. Canters, J.J. Davis, H.A.O. Hill, J. Crozier, M. Ph. Verbeet, C.W. Wrathmell, Y. Astier. The electrochemical characteristics of blue copper protein monolayers on gold. J. Electroanal. Chem. 2004, 565(1), 21-28. 9- Elizabeth. A. Bentley, Yann Astier*, Wen Ming Ji , Stephen. G. Bell, Luet-Lok Wong and H. Allen O. Hill. The electrochemistry and scanning tunnelling microscopy of the flavoprotein, putidaredoxin reductase on alkanethiol-modified gold. Inorganica Chimica Acta, 2003, 356C, 343-348 (*corresponding author) 8- Astier, Yann; Balendra, Suki; Hill, H. Allen O.; Smith, Thomas J.; Dalton, Howard. Cofactor-independent oxygenation reactions catalyzed by soluble methane monooxygenase at the surface of a modified gold electrode. European Journal of Biochemistry (2003), 270(3), 539-544. 7- Jacques Simonet, Yann Astier and Cecile Dano. On the cathodic behavior of tetraalkylammonium cations at a platinum electrode. J. Electrochem. Soc., 451 (1998), 5-9. 6- P.N.Bartlett and Y.Astier. Microelectrochemical enzyme transistors. Chem. Commun., 2000, 105-112. PATENTS 5- UK Patent application on “covalently attached cyclodextrin adapter inside the a-hemolysin nanopore” filed june 2007 by Isis Innovation 4- UK Patent application on “single molecule DNA sequencing “ International Patent Application number PCT/GB06/004265 filed on 15 November 2006 by Isis Innovation LICENCED BY OXFORD-NANOLABS JUNE 2007 3- M. Hyland, Y. Astier, “Electrochemical sensor” Oxford-Biosensors patent file n 6, Agent number 84036, No 0211449.4 Application: WO 2005-GB2544 20050629. Priority: GB 2004-14551 20040629. 2-Patent Analyte Measurement, SET & Area Compensation Emma Wallace, Yann Astier Priority UK 0211449.4 17/05/2002 PCT/GB2003/002150 16/05/2003 1-Patent Micro-ring Well Electrodes, Well Electrodes Mark Hyland, Kevin Lorimer, Neil Butler, Emma Wallace, Yann Astier Priority UK 0130684.4 21/12/2001 PCT/GB02/005911 23/12/2002

Work involving ITQB researchers published in PNAS