[SCAN] On the formation of N-Heterocyclic Carbene in Nucleosides

SCAN

Title: On the formation of N-Heterocyclic Carbene in Nucleosides

Speaker: Ana Petronilho

Affiliation: Bioorganometallic Chemistry Lab, ITQB NOVA

Abstract:

Sources and is a central modification of the genome involved in the regulation of cellular processes. From an organometallic chemistry perspective, alkylated nucleobase adducts are N-heterocyclic carbene (NHC) precursors with a very labile C-H bond. NHCs have been proposed as intermediates in a variety of processes occurring during DNA damage, but their active role in these processes is not yet clear. To examine their impact, we are currently developing synthetic methodologies for the synthesis of N-Heterocyclic carbenes derived from DNA adducts and evaluating how carbene formation affects base-pairing. Due to their molecular recognition properties, these complexes are, in addition, suitable candidates as anti-cancer agents. In this communication the work developed thus far will be discussed.

Keywords: DNA, RNA, Organometallic Chemistry, N-Heterocyclic carbenes