1st Scientific COLife Seminar
The first COLife Scientific Webinar with have guest Edith Heard, hosted virtually by Monica Dias at IGC. This Seminar series aims to bring renowned life sciences’ researchers working in scientific topics that integrate the research interests of the six COLife Research institutes.
| When |
02 Oct, 2020
from
02:00 pm to 03:00 pm |
|---|---|
| Add event to your calendar |
iCal
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Title: Exploring the mechanisms of gene silencing and chromosome 3D re-organisation during X-chromosome inactivation
Speaker: Edith Heard
Affiliation: European Molecular Biology LaboratoryHeidelberg , Germany
Host: Mónica Bettencourt-Dias
Abstract: X-chromosome inactivation during early female development is an essential epigenetic process that is required to achieve appropriate dosage for X-linked gene products. We are interested in understanding how the differential treatment of the two X chromosomes in the same nucleus is set up during development and how this differential expression is then maintained, or reversed in certain circumstances, either normally or in a disease context such as cancer. The establishment of X inactivation involves the non-coding Xist RNA that triggers chromosome-wide chromatin re-organisation and gene silencing. Our lab has provided recent insights into the nature of these chromosome-wide changes, and the factors that induce them. These include the Xist-mediated recruitment of the SPEN protein to actively transcribed genes that triggers gene silencing and dampens expression of genes that escape XCI1. The loss of active chromatin marks as well as the global loss of topologically associating domains (TADs) are also early events during XCI2. Our recent insights into the relationship between chromatin states, 3D organisation and the events underlying X-linked gene silencing and escape from XCI will be presented.
Virtual Room: https://us02web.zoom.us/j/89418814083?pwd=VVZCWHBKdjU3UGpBTk9BeVFWMlN1UT09
Passcode: 514036
