[SCAN] 50 years of structural biology by paramagnetic NMR spectroscopy
Ricardo Louro
| When |
24 Nov, 2021
from
12:00 pm to 01:00 pm |
|---|---|
| Where | ITQB NOVA Auditorium |
| Contact Name | Rita Abranches |
| Add event to your calendar |
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Title: 50 years of structural biology by paramagnetic NMR spectroscopy
Speaker: Ricardo Louro
Abstract: “If you want to understand function, study structure” Francis Crick
Approximately 40% of the proteome of living organisms is constituted by metalloproteins of which a substantial fraction are metalloenzymes that contain transition metals with partially filled d-orbitals. These unpaired electrons generate paramagnetic effects in their vicinity that can be used to define the structure and dynamics of metalloproteins in solution, at temperature and pH conditions that mimetize the physiological environment.
The use of paramagnetic effects as sole structural constrains to determine the structure of a metalloprotein is an endeavour pursued for many years that has now been achieved.
I will present the context of this development, how it was achieved and the outlook and opportunities that it offers for understanding biological function through structure.
ITQB NOVA Virtual Auditorium
https://us06web.zoom.us/j/84414201190
