[SCAN] Integrated proteomics and metabolomics contribute to fight infectious diseases
Ana Coelho
| When |
03 Nov, 2021
from
12:00 pm to 01:00 pm |
|---|---|
| Where | ITQB NOVA Auditorium |
| Contact Name | Rita Abranches |
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Title: Integrated proteomics and metabolomics contribute to fight infectious diseases
Speaker: Ana Coelho
Abstract: Tuberculosis (TB) is a transmissible disease listed as one of the 10 leading causes of death worldwide (10 million infected in 2019). Additionally, WHO recently reported that tuberculosis deaths raised for the first time in more than a decade due to the COVID-19 pandemic. A swift and precise diagnosis is essential to forestall its transmission, for which is crucial the discovery of effective diagnostic biomarkers. Blood serum samples from a cohort including healthy individuals (H) and patients (P) were submitted to LC-MS/MS for differential proteomics and metabolomics. High selectivity and specificity were determined for the fourteen elected biomarkers (four proteins and ten metabolites), for which 100% correct assignment was obtained for the prediction set (n=8). Validated biomarkers will be of potential use for the development of a point-of-care diagnosis clinical test.
Staphylococcus epidermidis include the skin microbiota and contribute to homeostasis and protection against pathogens. However, they are the most frequent cause of medical device-associated infections. Skin isolates belonging to clonal complex 2 (CC2) lineage are the major colonizers sharing their ecological niche with other minor genetic backgrounds (non-CC2). CC2 strains are the more frequent in infection. Strains from each lineage display totally different metabolic and phenotypic profiles in the same environmental conditions, suggesting that they play specific roles in skin ecology. Overall, having the opportunity, CC2 strain appears to be better equipped to cause infection than non-CC2 strain. Understanding the differences in the metabolic and biological processes between the two types of commensal SE strains constitutes a major starting point for the design of specific antimicrobials toward the pathogenic strains.
https://us06web.zoom.us/j/84414201190
