[SCAN] Peptide-mediated systems to understand the natural processes of the biological systems and its organization
Ana Pina
| When |
19 Jan, 2022
from
12:00 pm to 01:00 pm |
|---|---|
| Contact Name | Rita Abranches |
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Title: Peptide-mediated systems to understand the natural processes of the biological systems and its organization
Speaker: Ana Pina
Abstract:
The complexity of the living systems arises from chemical reactions involving molecular interactions between proteins, giving rise to function. Also living cells, organize their complex biochemical reactions by creating compartments through phase transition, controlling thus diverse reactions in space and time.
Peptides are components of the biological systems and present a vast chemical information that can be modulated to perform life-like functions (e.g., molecular recognition, catalysis, molecular assembly) with reduced overall complexity. In addition, multicomponent peptide interactions can evolve to more complex, dynamic, and functional systems, providing a mean to understand the complexity and organization of biological systems.
We are currently working on the mapping of the peptide sequence space to develop short functional peptide modules for a variety of functions, and to establish sequence-order-function principles, important for molecular recognition, reactivity, and catalysis, and ultimately to understand membraneless cellular compartmentalization: By integrating all these functions and understanding the chemical patterns of the peptide motifs involved in the driving of the natural phase transition in membraneless compartmentalization, we aim to program peptides into functional artificial compartments as protocells mimetics, for further applications in biomedical tools and diagnosis, bioelectronics, etc.
