SCAN:Human Cytomegalovirus full length virion fusion protein for vaccine and drug target development

ITQB Scan Seminar

Title: Human Cytomegalovirus full length virion fusion protein for 
vaccine and drug target development

Speaker: Marco Patrone

From: PhD At Animal Technology Unit

Abstract:

HCMV infection is a major cause of morbidity and mortality in humans with 
acquired or developmental deficits in innate and adaptative immunity: it 
is a common source of life-threatening complications in transplant 
recipients and the leading infectious cause of neurodevelopmental 
congenital abnormalities. On the other hand, HCMV infection represents a 
continuous challenge for the immune system in immunocompetent individuals, 
causing a persistent state of local but disseminated inflammation.
A major effort is currently underway to develop an effective vaccine and 
reduce the socio-economic burden caused by this endemic pathogen. The 
ongoing work presented here aims to contribute to this goal by exploring 
alternative design for one of the major vaccine targets and offers an 
example of bioprocess development for challenging proteins.