[SCAN] Investigating Terminal mRNA Uridylation in Fission Yeast
Michal Malecki, IMM & ITQB NOVA Alumni
| When |
17 Jan, 2024
from
12:00 pm to 01:00 pm |
|---|---|
| Where | ITQB NOVA Auditorium |
| Contact Name | Sandra Viegas |
| Contact Email | sviegas@itqb.unl.pt |
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Title: Investigating Terminal mRNA Uridylation in Fission Yeast
Speaker: Michal Malecki
From: IMM and ITQB NOVA Alumni
Abstract: Cytoplasmic mRNA decay occurs through exonucleolytic degradation in either the 5' to 3' or 3' to 5' direction. Widespread terminal uridylation is implicated in mRNA degradation. However, despite its conservation throughout eukaryotes, its specific functional relevance in bulk mRNA turnover remains poorly understood.
In our laboratory, we utilized fission yeast as a model system to explore the function of terminal uridylation in mRNA turnover.
Leveraging yeast genetics and genome-wide RNA 3’-end sequencing, we revealed the existence of two types of terminal uridylation in S. pombe, catalyzed by distinct terminal uridyltransferases. Our findings suggest that uridylation supports mRNA decay in both directions and plays a role in regulating the directionality of mRNA decay.
