[SCAN] Protein disorder–order interplay
Tiago N. Cordeiro
| When |
17 Jun, 2020
from
12:00 pm to 01:00 pm |
|---|---|
| Where | Zoom Webinar |
| Contact Name | Rita Abranches |
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Title: Protein disorder–order interplay
Speaker: Tiago N. Cordeiro
Affiliation: Dynamic Structural Biology Lab - Tiago N. Cordeiro Lab
Host: Adriano Henriques
Abstract: Proteins adopt “orders of disorder”, spanning from fully and intrinsically disordered entities to well folded and structured ones. The interplay between structured and disordered regions is essential to interact with binding partners or perform the chemical reactions required for key cellular processes. However, assigning a direct functional role to this interplay has proved challenging. Herein, we present our efforts towards understanding the role of protein disorder/order in cell regulation, signalling, and enzymatic activity from an integrative structural biology perspective (i.e., SAXS, NMR, X-ray). We are tackling this challenge while studying: 1) the pathogenic disordered protein Tir, a multifaceted bacterial effector essential for Enterohemorrhagic (EHEC) and Enteropathogenic (EPEC) Escherichia coli virulence; 2) the structural properties of ubiquitylated p15, a disordered protein overexpressed in cancer; and 3) the conformational landscape of McoA, multicopper oxidases from the hyperthermophilic bacteria Aquifex aeolicus.
Zoom webinar - ITQB NOVA Virtual auditorium
