[Seminar] Discovery of New Platforms for Stimuli-Responsive Targeting Drug Conjugates

Title: Discovery of new Platforms for Stimuli-Responsive Targeting Drug Conjugates

Speaker: Pedro Gois  - Research Institute for Medicines (iMed.ULisboa) Pharmacy Faculty, Universidade de Lisboa

Abstract:

Targeting drug conjugates, emerged as a powerful class of chemotherapeutic agents that are capable of sparing healthy tissues by liberating the cytotoxic payload upon specific antigen recognition. A considerable body of work in this field highlighted that targeting drug conjugates therapeutic efficacy, correlates well with the conjugate homogeneity and activation of the drug at the diseased site. Therefore, the linker technology used to connect both functions contributes decisively to the therapeutic usefulness of these constructs. In this communication will be presented our most recent finding on the design of functional likers for targeting drug conjugates, based on boron complexes (B-complexes)¹ that can be modulated to exhibit fluorescence and to respond to glutathione, pH or reactive oxygen species stimulus.^2-4

Zoom link: https://us06web.zoom.us/j/87937938496

References:

[1] J. P. M. António, Roberto Russo, C. P. Carvalho, Pedro M. S. D. Cal, Pedro M. P. Gois, Chem. Soc. Rev. 2019, 48, 3513.
[2] R. M. R. M. Lopes, A. E. Ventura, L. C. Silva, H. Faustino, P. M. P. Gois, Chem. Eur. J. 2018, 24, 12495.
[3] F. M. F. Santos, A. I. Matos, A. E. Ventura, J. Gonçalves, L. F. Veiros, H. F. Florindo, P. M. P. Gois, Angew. Chem. Int. Ed. 2017, 56, 9346.
[4] António, J. P. M.; Carvalho, J. I.; André, A. S.; Dias, J. N. R.; Aguiar, S. I.; Faustino, H.; Lopes, R. M. R. M.; Veiros, L. F.; Bernardes, G. J. L.; Silva, F. A.; Gois, P. M. P. Angew. Chemie Int. Ed. 2021, 60, 25914.