[Seminar] Mycobacterial GroEL's: Moonlighting in Non-specific Binding
Shekhar Mande, National Centre for Cell Science, NCCS Complex, INDIA
| When |
20 Dec, 2016
from
11:00 am to 12:00 pm |
|---|---|
| Where | Auditorium |
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Seminar
Title: Mycobacterial GroEL's: Moonlighting in Non-specific Binding
Speaker: Shekhar Mande
Affiliation: Director, National Centre for Cell Science, NCCS Complex, Pune University Campus, Ganeshkhind, INDIA
Abstract:
GroEL belongs to a class of molecular chaperones, often referred to as the Chaperonins. Its primary role has been defined as that protein which binds non-specifically to unfolded substrate proteins, and mediates their folding/ assembly/ transport via ATP-mediated cycles of binding and release. The defining characteristics for this function is the oligomeric status of GroEL, which is required to sequestrate the substrates. We discovered a few years ago that in some species, the paralogous copies of GroEL either fail to form oligomers, or are able to form oligomers only by regulated manner. These GroEL's are likely to possess Moonlighting functions. I will highlight these during my presentation.
