[Seminar] Unfolded Protein Response in Drosophila development, disease and lifespan
Hyung Don Ryoo, New York University School of Medicine, USA
| When |
14 Dec, 2015
from
12:00 pm to 01:00 pm |
|---|---|
| Where | Auditorium |
| Add event to your calendar |
iCal
|
Seminar
Title: Unfolded Protein Response in Drosophila development, disease and lifespan
Speaker: Hyung Don Ryoo
Affiliation: New York University School of Medicine
Host: Pedro Domingos, Cell Signaling in Drosophila Lab
Abstract:
My laboratory is primarily interested in understanding how the Unfolded Protein Response pathways help to protect cells against misfolded protein overload in the endoplasmic reticulum (ER), and why certain conditions lead to the death of vital cells to cause degenerative diseases. I use primarily a Drosophila model for Retinitis Pigmentosa, in which mutant rhodopsins cause age-related loss of photoreceptors. During this course, we demonstrated that the retinal degeneration in this model is caused by rhodopsin misfolding in the endoplasmic reticulum, and the ensuing Unfolded Protein Response pathways help to protect young photoreceptors by inducing chaperones and rhodopsin degrading enzymes. In addition, we identified previously unrecognized factors that mediate photoreceptor degeneration. More recently, my group has focused on aspects of the Unfolded Protein Response that have been overlooked by others. In one particular project, we are examining a specific branch of the Unfolded Protein Response that also responds to dietary restriction of amino acids. We find that this pathway, mediated by ATF4, regulates protein translation in a manner more intricate than had been previously thought. Moreover, our evidence indicates that the newly identified mechanisms contribute to the effect of dietary restriction of amino acids on Drosophila lifespan extension. This has prompted us to go beyond the analysis of transcriptome changes in response to stress, and we are currently developing new techniques to directly profile protein translation in Drosophila.
Speaker's short biography
1991 - B.A. Biochemistry, Yonsei University (Seoul, Korea).
2000 - Ph.D. Biochemistry, Columbia University (New York, U.S.A.).
2000 – 2005 Postdoc with Hermann Steller, The Rockefeller University, HHMI
2005 – 2011 Assistant Professor of Cell Biology , NYU School of Medicine.
2011 – Associate Professor of Cell Biology, NYU School of Medicine.
