Synthesis and biological applications of peptide dendrimers

ITQB Seminar

Title: Synthesis and biological applications of peptide dendrimers

Speaker: Tamis Darbre

Affiliation: Department of Chemistry and Biochemistry, University of Bern,  Switzerland

Host: António Baptista Head of Molecular Simulation Laboratory

Abstract:

Peptide dendrimers are composed of amino acids and diamino acids as branching units to give a peptides with a globular topology. Solid phase peptide synthesis has been adapted in our laboratory for the synthesis of peptide dendrimers. Methods to generate split-and-mix combinatorial libraries were also developed. Libraries with 20000 or more sequences were screened for several applications including catalysis and lectin binding.
Inhibitors of biofilm formation by the pathogenic bacterium Pseudomonas aeruginosa were developed with glycopeptide dendrimers. Further applications such as antimicrobial or cell penetrating peptide dendrimers are also under investigation.