Best PhD Thesis Prize 2010
Supervised by Manuel Carrondo, head of the Engineering Cellular Applications Laboratory, and Rui Oliveira, from Requimte/FCT-UNL, António Roldão received his PhD in Engineering and Technology Sciences on June 2010. The thesis is entitled “Production Optimization of Rotavirus-Like Particles: A Systems Biology Approach”.
The thesis intends to provide a set of computational models and algorithms, which represent a step forward to the in silico implementation of the baculovirus/insect cells system, to assist the design of novel and improved optimization schemes for the production of virus particles, viral proteins and/or complex protein structures such as virus-like particles
The award, now in its second edition, aims to recognize the best PhD thesis presented at ITQB in 2010. The prize money of 2,500 Euros is funded by Fundação Jacqueline Dias de Sousa. The selection panel was chaired by Cândido Pinto Ricardo from ITQB.
Genetic/molecular regulatory network of RLPs production in the baculovirus/insect cell system. The arrows and represent transport of material and interaction between structures, respectively. In each genetic regulation networks, the line and the arrows and indicate an interaction between two genes, the stimulation of one gene by a second gene and the stimulation of one gene by itself, respectively. The genes directly involved in vDNA replication and transcription are underlined.