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Tasty and healthy

Researchers found berries’ metabolites that can be neuroprotective

Oeiras, 18.09.2017

Age-related complications such as neurodegenerative disorders are increasing and remain cureless. The possibility of altering the progression or the development of these multifactorial diseases through diet is an emerging and attractive approach with increasing experimental support.

Researchers from Molecular Nutrition and Health lab from ITQB NOVA and iBET, in collaboration with James Hutton Institute and Faculty of Pharmacy from Lisbon, have examined the potential of known bioavailable phenolic sulfates, arising from colonic metabolism of berries, to influence hallmarks of neurodegenerative processes. The results were published in Scientific Reports.

“We have found that when consumed, berries are metabolized into molecules that can reach the brain in considerable amounts”, according to Cláudia Santos, coordinator of the project. “These metabolites also displayed strong neuroprotective potential towards important hallmarks of neurodegenerative diseases such as oxidative stress, glutamate excitotoxicity and neuroinflammation”.


Original article

Scientific Reports 7, Article number: 11456 (2017)

Polyphenols journey through blood-brain barrier towards neuronal protection

I. Figueira, G. Garcia, R. C. Pimpão, A. P. Terrasso, I. Costa, A. F. Almeida, L. Tavares, T. F. Pais, P. Pinto, M. R. Ventura, A. Filipe, G. J. McDougall, D. Stewart, K. S. Kim, I. Palmela, D. Brites, M. A. Brito, C. Brito & C. N. Santos


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