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Severe human genetic diseases are related to malfunctioning ribosomes. The surveillance system of this protein collaboration was previously unknown.

A method to estimate the strength of a carbon-carbon double bond

Luís Goulão, Plant Cell Wall Laboratory

Werner Kühlbrant, Max Planck Institute of Biophysics, Frankfurt, Germany

Researchers characterize spore formation in Clostridium difficile

PUBLICATIONS and PATENTS 20- Yann Astier, Denis E. Kainov, Hagan Bayley, Roman Tuma, Stefan Howorka,”Stochastic Detection of Motor Protein-RNA Complexes by single channel current recording” Chem. Phys Chem. 2007, 8, 2189 – 2194. 19- Haichen Wu, Yann Astier, Giovanni Maglia, Ellina Mikhailova and Hagan Bayley “a-Hemolysin pores with covalently attached molecular adapters” J. Am. Chem. Soc.( 2007), 129 (51), 16142-16148. 18- Hugh Martin,†,§ Helen Kinns,†,§ Nick Mitchell,† Yann Astier,‡ Hagan Bayley,‡ Stefan Howorka†, “Nanoscale protein pores modified with PAMAM dendrimers” J. Am. Chem. Soc.( 2007), 129 (31), 9640 -9649 17- A 'pore' man's sequencing solution? Michael Eisenstein, Nature Methods, Research Highlights, 3, 157 (2006). Covering Astier et al. J. Am. Chem. Soc. (2006), 128(5) 1705-1710 16- Yann Astier, Orit Braha, Hagan Bayley, “Towards single molecule DNA sequencing: direct identification of 5’ monophosphate ribo and deoxy-ribo nucleotides with a protein nanopore equipped with a molecular adapter.” J. Am. Chem. Soc. (2006), 128(5) 1705-1710 15- Yann Astier, Hagan Bayley, Stefan Howorka, “Protein components for nanodevices” Curr Opin Chem Biol 2005, 9:576-584. 14- Yann Astier, Gerard W. Canters, Jason J. Davis, H. Allen O. Hill, Martin P. Verbeet, Hein J. Wijma, “Sensing nitrite through a pseudoazurin-nitrite reductase electron transfer relay “ Chem. Phys. Chem. 2005, 6, 1114-1120. 13- Y. Astier*, A. Bond, H. Wijma, G. W. Canters, H. A. O. Hill, J. J. Davis. A systematic study of the influence of peptide modification of a gold electrode on the electrochemistry of pseudoazurin. Electroanalysis (2004), 16(13-14), 1155-1165. (*corresponding author) 12- Y. Astier, P. N. Bartlett, “The measurement of alkaline phosphatase at nanomolar concentration within 70 s using a disposable microelectrochemical transistor.” Bioelectrochemistry (2004), 64(1), 53-59. 11- Y. Astier, P. N. Bartlett. The demonstration of an enhanced microelectrochemical transistor for measurements in neutral solution at low analyte concentration. Bioelectrochemistry (2004), 64(1), 15-22. 10- L. Andolfi, D. Bruce, S. Cannistraro, G.W. Canters, J.J. Davis, H.A.O. Hill, J. Crozier, M. Ph. Verbeet, C.W. Wrathmell, Y. Astier. The electrochemical characteristics of blue copper protein monolayers on gold. J. Electroanal. Chem. 2004, 565(1), 21-28. 9- Elizabeth. A. Bentley, Yann Astier*, Wen Ming Ji , Stephen. G. Bell, Luet-Lok Wong and H. Allen O. Hill. The electrochemistry and scanning tunnelling microscopy of the flavoprotein, putidaredoxin reductase on alkanethiol-modified gold. Inorganica Chimica Acta, 2003, 356C, 343-348 (*corresponding author) 8- Astier, Yann; Balendra, Suki; Hill, H. Allen O.; Smith, Thomas J.; Dalton, Howard. Cofactor-independent oxygenation reactions catalyzed by soluble methane monooxygenase at the surface of a modified gold electrode. European Journal of Biochemistry (2003), 270(3), 539-544. 7- Jacques Simonet, Yann Astier and Cecile Dano. On the cathodic behavior of tetraalkylammonium cations at a platinum electrode. J. Electrochem. Soc., 451 (1998), 5-9. 6- P.N.Bartlett and Y.Astier. Microelectrochemical enzyme transistors. Chem. Commun., 2000, 105-112. PATENTS 5- UK Patent application on “covalently attached cyclodextrin adapter inside the a-hemolysin nanopore” filed june 2007 by Isis Innovation 4- UK Patent application on “single molecule DNA sequencing “ International Patent Application number PCT/GB06/004265 filed on 15 November 2006 by Isis Innovation LICENCED BY OXFORD-NANOLABS JUNE 2007 3- M. Hyland, Y. Astier, “Electrochemical sensor” Oxford-Biosensors patent file n 6, Agent number 84036, No 0211449.4 Application: WO 2005-GB2544 20050629. Priority: GB 2004-14551 20040629. 2-Patent Analyte Measurement, SET & Area Compensation Emma Wallace, Yann Astier Priority UK 0211449.4 17/05/2002 PCT/GB2003/002150 16/05/2003 1-Patent Micro-ring Well Electrodes, Well Electrodes Mark Hyland, Kevin Lorimer, Neil Butler, Emma Wallace, Yann Astier Priority UK 0130684.4 21/12/2001 PCT/GB02/005911 23/12/2002