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Single Molecule Processes


Research Interests

As a group, our interests lie in the study and development of both biological and solid-state nanopores. We use alpha-hemolysin as a nanotool for investigating the binding and properties of various small molecules or nanoparticles (analytes). Such studies allow us to assess the degree of purity or the heterogeneity of a given analyte.

We hope to transfer insight, gained from these studies, to the development of solid-state nanopores for applications in detection. Solid-state nanopores can be manufactured in ultrathin membranes of silicon nitride or silicon oxide or in polymers such as polycarbonate or PET.

We strive to develop solid-state nanopores for applications in defence, civil security, airport security, food safety, monitoring the quality of drinking water, drug detection, drug testing and medical diagnostics.


Selected Publications

  1. Astier Y, Uzun O, Stellacci F. Electrophysiological study of single gold nanoparticle/alpha-Hemolysin complex formation: a nanotool to slow down ssDNA through the alpha-Hemolysin nanopore. Small (2009) 5(11):1273-8.
  2. Astier Y, Datas L, Carney R, Stellacci F, Gentile F, DiFabrizio E. Artificial surface-modified Si₃N₄ nanopores for single surface-modified gold nanoparticle scanning. Small (2011) 7(4):455-9.
  3. Campos E, Asandei A, McVey CE, Dias JC, Oliveira AS, Soares CM, Luchian T, Astier Y. The role of Lys147 in the interaction between MPSA-gold nanoparticles and the α-hemolysin nanopore. Langmuir (2012) 28(44):15643-50
  4. Carney RP, Astier Y, Carney TM, Voïtchovsky K, Jacob Silva PH, Stellacci F.
    Electrical method to quantify nanoparticle interaction with lipid bilayers. ACS Nano (2013) 7(2):932-42.




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