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Proteome Regulation in Plants


At the Proteome Regulation in Plants Laboratory we study the effects of post-translational modifications on protein function. Our working hypothesis is that the plant proteome can be induced to rapidly and efficiently deal with environmental changes, by manipulating its global regulation by post-translational modifications.

Isabel A. Abreu
Investigador Principal
PhD in Biochemistry, 2002, ITQB NOVA

Phone (+351) 214469647
Extension 1647


Research Interests

We are at a standstill in what comes to crop yield production and the demand for yield increase is adamant, mostly due to the population growth. Adding to this, there is the obvious climate unpredictability that is affecting regular crop production.

To address these questions, scientists are searching for new ways to improve C- fixation/photosynthesis and to increase plant tolerance to stress. We are engaged in this effort by exploring the regulation of key proteins by post-translational modifications (PTMs). There is an obvious lack of knowledge in plants regarding how PTMs regulate the proteome, as compared to what is known in the animal-field. Because PTMs can act in the cell proteome to rapidly change its properties, our hypothesis is that by “manipulating” these mechanisms, we may prepare the cell for a first line of response (rapid response) to environmental changes. This novel approach will hopefully contribute with new plant improvement strategies.


Group Members


  • Bruno Alexandre, Post Doc
  • Cátia Nunes, Post Doc
  • Margarida Rosa, PhD student
  • Mafalda Rodrigues, PhD student
  • Nuno Gonçalves, PhD student
  • Cecília Pina, PhD student (Co-supervision)
  • André Cordeiro, PhD student (Co-supervision)
  • Vanessa Azevedo, MSc (Lab Manager)


Selected Publications

  1. Almeida DM*, Almadanim MC*, Lourenço T, Abreu IA, Saibo NJM, Oliveira MM. Screening for abiotic stress tolerance in rice: salt, cold and drought. In: Duque P (ed). Environmental Responses in Plants, Springer, New York, NY, USA. Volume 1398 of the series Methods in Molecular Biology pp 155-18. (*both authors contributed equally to this manuscript.)

  2. Sheng Y, Abreu IA*, Cabelli DE, Maroney MJ, Miller A-F, Teixeira M, Valentine JS (2014) Superoxide Dismutases and Superoxide Reductases. Chem. Rev. 114:3854-918.

  3. Abreu IA, Farinha AP, Negrão S, Gonçalves N, Fonseca C, Rodrigues M, Batista R, Saibo NJM, Oliveira MM. (2013) Coping with abiotic stress: Proteome changes for crop improvement. J Prot, 93:145-168.

Laboratory's Website

For further information please visit the GPlantS website

For further information please visit the laboratory's (Plant Functional Genomics) website





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