Publications

Thank you for acknowledging the Bacterial Imaging Cluster and the Portuguese Platform of BioImaging!

This work was partially supported by PPBI - Portuguese Platform of BioImaging (PPBI-POCI-01-0145-FEDER-022122) co-funded by national funds from OE - "Orçamento de Estado" and by european funds from FEDER - "Fundo Europeu de Desenvolvimento Regional".

📌 If you used the BIC, please acknowledge us and let us know (bic@itqb.unl.pt) — we’ll feature your work here!

2025

• Piontkivska D, et al. Hidden Allies: Decoding the Core Endohyphal Bacteriome of Aspergillus fumigatus. Environ Microbiol Rep. 2025;17(1):1-10. doi:10.1111/1758-2229.70153

• Santos CC, Schweizer N, Cairrão F, et al. Fbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling. Nat Commun. 2025;16:7523. doi:10.1038/s41467-025-62417-2

2024

• Martins D, Nerber HN, Roughton CG, et al. Cleavage of an engulfment peptidoglycan hydrolase by a sporulation signature protease in Clostridioides difficile. Mol Microbiol. 2024;122(2):213–229. doi:10.1111/mmi.15291

• Osborne MS, Brehm JN, Olivença C, Cochran AM, Serrano M, Henriques AO, Sorg JA. The impact of YabG mutations on Clostridioides difficile spore germination and processing of spore substrates. Mol Microbiol. 2024;122(4):534–548. doi:10.1111/mmi.15316

• Schäper S, Brito AD, Saraiva BM, et al. Cell constriction requires processive septal peptidoglycan synthase movement independent of FtsZ treadmilling in Staphylococcus aureus. Nat Microbiol. 2024;9(4):1049–1063. doi:10.1038/s41564-024-01629-6

• Reis DQP, Pereira S, Ramos AP, et al. Catalytic peptide-based coacervates for enhanced function through structural organization and substrate specificity. Nat Commun. 2024;15:9368. doi:10.1038/s41467-024-53699-z

• Cassona CP, Ramalhete S, Amara K, et al. Spores of Clostridioides difficile are toxin delivery vehicles. Commun Biol. 2024;7(1):839. doi:10.1038/s42003-024-06521-x

2023

• Marini E, Olivença C, Ramalhete S, Aguirre AM, Ingle P, Melo MN, et al. A sporulation signature protease is required for assembly of the spore surface layers, germination and host colonization in Clostridioides difficile. PLoS Pathog. 2023;19(11):e1011741. doi:10.1371/journal.ppat.1011741

2022

• Bárria C, Mil-Homens D, Pinto SN, Fialho AM, Arraiano CM, Domingues S. RNase R, a New Virulence Determinant of Streptococcus pneumoniae. Microorganisms. 2022;10(2):317. doi:10.3390/microorganisms10020317.

• Cairrão F, Santos CC, Le Thomas A, Marsters S, Ashkenazi A, Domingos PM, et al. Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay. Nat Commun. 2022;13(1):1587. doi:10.1038/s41467-022-29105-x.

2021

• Gaspar CJ, Vieira LC, Santos CC, et al. EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel. EMBO Rep. 2021;23:e53210. doi:10.15252/embr.202153210

• Valente C, Cruz AR, Henriques AO, Sá-Leão R. Intra-Species Interactions in Streptococcus pneumoniae Biofilms. Front Cell Infect Microbiol. 2021;11. doi:10.3389/fcimb.2021.803286.

• Martins D, DiCandia MA, Mendes AL, et al. CD25890, a conserved protein that modulates sporulation initiation in Clostridioides difficile. Sci Rep. 2021;11(1):7887. doi:10.1038/s41598-021-86878-9

2020

• Silva A V., Edel M, Gescher J, Paquete CM. Exploring the Effects of bolA in Biofilm Formation and Current Generation by Shewanella oneidensis MR-1. Front Microbiol. 2020;11. doi:10.3389/fmicb.2020.00815

• Do T, Schaefer K, Santiago AG, et al. Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan. Nat Microbiol. 2020;5(2):291-303. doi:10.1038/s41564-019-0632-1

2019

• Silva JPN, Lopes SV, Grilo DJ, Hensel Z. Plasmids for Independently Tunable, Low-Noise Expression of Two Genes. Ellermeier CD, ed. mSphere. 2019;4(3). doi:10.1128/mSphere.00340-19

• Reichmann NT, Tavares AC, Saraiva BM, et al. SEDS-bPBP pairs direct lateral and septal peptidoglycan synthesis in Staphylococcus aureus. Nat Microbiol. 2019;4(8):1368-1377. doi:10.1038/s41564-019-0437-2

• Fernandes CG, Martins D, Hernandez G, et al. Temporal and spatial regulation of protein cross-linking by the pre-assembled substrates of a Bacillus subtilis spore coat transglutaminase. PLoS Genet. 2019;15(4):e1007912. doi:10.1371/journal.pgen.1007912

• Santos RB, Pires AS, van der Hoorn RAL, Schiermeyer A, Abranches R. Generation of transgenic cell suspension cultures of the model legume Medicago truncatula: a rapid method for Agrobacterium mediated gene transfer. Plant Cell, Tissue Organ Cult. 2019;136(3):445-450. doi:10.1007/s11240-018-1525-3

• Pereira FC, Nunes F, Cruz F, et al. A LysM Domain Intervenes in Sequential Protein-Protein and Protein-Peptidoglycan Interactions Important for Spore Coat Assembly in Bacillus subtilis. J Bacteriol. 2019;201(4). doi:10.1128/JB.00642-18

• Hill MA, Lam AK, Reed P, et al. BPEI-Induced Delocalization of PBP4 Potentiates β-Lactams against MRSA. Biochemistry. 2019;58(36):3813-3822. doi:10.1021/acs.biochem.9b00523

• Monteiro JM, Covas G, Rausch D, et al. The pentaglycine bridges of Staphylococcus aureus peptidoglycan are essential for cell integrity. Sci Rep. 2019;9(1):5010. doi:10.1038/s41598-019-41461-1

2018

• Fernandes CG, Moran CP, Henriques AO. Autoregulation of SafA Assembly through Recruitment of a Protein Cross-Linking Enzyme. Henkin TM, ed. J Bacteriol. 2018;200(14). doi:10.1128/JB.00066-18

• Nunes F, Fernandes C, Freitas C, et al. SpoVID functions as a non-competitive hub that connects the modules for assembly of the inner and outer spore coat layers in Bacillus subtilis. Mol Microbiol. 2018;110(4):576-595. doi:10.1111/mmi.14116

• Monteiro JM, Pereira AR, Reichmann NT, et al. Peptidoglycan synthesis drives an FtsZ-treadmilling-independent step of cytokinesis. Nature. 2018;554(7693):528-532. doi:10.1038/nature25506

2017

• Hensel Z. A plasmid-based Escherichia coli gene expression system with cell-to-cell variation below the extrinsic noise limit. PLoS One. 2017;12(10):e0187259. doi:10.1371/journal.pone.0187259

• Catteau L, Reichmann N, Olson J, et al. Synergy between Ursolic and Oleanolic Acids from Vitellaria paradoxa Leaf Extract and β-Lactams against Methicillin-Resistant Staphylococcus aureus: In Vitro and In Vivo Activity and Underlying Mechanisms. Molecules. 2017;22(12):2245. doi:10.3390/molecules22122245

• Reichmann NT, Pinho MG. Role of SCCmec type in resistance to the synergistic activity of oxacillin and cefoxitin in MRSA. Sci Rep. 2017;7(1):6154. doi:10.1038/s41598-017-06329-2

• Nair DR, Chen J, Monteiro JM, et al. A quinolinol-based small molecule with anti-MRSA activity that targets bacterial membrane and promotes fermentative metabolism. J Antibiot (Tokyo). 2017;70(10):1009-1019. doi:10.1038/ja.2017.79