Our main research interests can be divided in three major topics.
Hydrogen sulfide (H2S) metabolism in human (patho)physiology
- crosstalk between the gasotransmitters NO, CO and H2S
- structure, function and pharmacological targeting of proteins involved in the metabolism and
- signalling pathways of reactive sulfur species
- cysteine post-translational modifications
Protein (mis)folding in disease
- structure-function relationships in pathogenic variants of enzymes related to inborn errors of metabolism and cancer
- small molecule-based alternative therapies
Development of innovative computationally designed therapeutic proteins
- engineering and production of computationally generated recombinant protein designs
- design and production of immunogenic nanoparticles for drug delivery
- interaction with targets by biophysical methods
O grupo de Bioquímica Aplicada de Proteínas combina bioquímica e biofísica de proteínas com biologia estrutural para investigar a (disf)função de proteínas em contextos patofisiológicos específicos, e para desenhar e desenvolver proteínas com potencial biofarmacêutico/biotecnológico.
As principais áreas de investigação actualmente são:
- Metabolismo humano do sulfureto de hidrogénio e (pato)fisiologia
- Proteínas ‘desordeiras’ no contexto de doença
- Desenvolvimento de proteínas terapêuticas inovadoras desenhadas computacionalmente
