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2024

  1. Vaz TA, Rodrigues AF, Coroadinha AS. Exploring nutrient supplementation and bioprocess optimization to improve the production of lentiviral vectors in serum-free medium suspension cultures. Biotechnol J. 2024;19(1):e2300212. doi: 10.1002/biot.202300212
  2. Paz-Artigas L, González-Lana S, Polo N, Vicente P, Montero-Calle P, Martínez MA, Rábago G, Serra M, Prósper F, Mazo MM, González A, Ochoa I, Ciriza J. Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays. ACS Biomater Sci Eng. 2024. 10(2):987-997. doi: 10.1021/acsbiomaterials.3c01302
  3. Carvalho SB, Profit L, Krishnan S, Gomes RA, Alexandre BM, Clavier S, Hoffman M, Brower K, Gomes-Alves P. SWATH-MS as a strategy for CHO host cell protein identification and quantification supporting the characterization of mAb purification platforms. J Biotechnol. 2024. 20;384:1-11. doi: 10.1016/j.jbiotec.2024.02.001
  4. Louro AF, Meliciano A, Alves PM, Costa MHG, Serra M. A roadmap towards manufacturing extracellular vesicles for cardiac repair. Trends Biotechnol. 2024. 42(10):1305-1322. doi: 10.1016/j.tibtech.2024.03.010
  5. Gomes CM, Sebastião MJ, Silva G, Moura F, Simão D, Gomes-Alves P, Alves PM, Brito C. Miniaturization of hiPSC-derived 3D neural cultures in stirred-tank bioreactors for parallelized preclinical assessment of rAAV. Front Bioeng Biotechnol. 2024.12:1379597. doi: 10.3389/fbioe.2024.1379597
  6. Janssen J, Chirico N, Ainsworth MJ, Cedillo-Servin G, Viola M, Dokter I, Vermonden T, Doevendans PA, Serra M, Voets IK, Malda J, Castilho M, van Laake LW, Sluijter JPG, Sampaio-Pinto V, van Mil A. Hypothermic and cryogenic preservation of cardiac tissue-engineered constructs. Biomaterials Science. 2024. 12(15) 3866-3881. doi: 10.1039/d3bm01908j
  7. Rodrigues MQ, Patão S, Thomaz M, Nunes T, Alves PM, Roldão A. Tyrosinase‑Mediated Conjugation for Antigen Display on Ferritin Nanoparticles. Bioconjugate Chemistry. 2024. 35(10): 1608–1617. doi:10.1021/acs.bioconjchem.4c00387
  8. Correia R, Fernandes B, Alves PM, Roldão A. Adaptive Laboratory Evolution to Improve Recombinant Protein Production Using Insect Cells. In: Methods in Molecular Biology, vol. 2829. Springer; 2024:79–90. doi:10.1007/978-1-0716-3961-0_6
  9. Vicente P, Almeida JI, Crespo IE, Virgolini N, Isidro IA, Calleja-Cervantes ME, Rodriguez-Madoz JR, Prosper F, Alves PM, Serra M. Oxygen control in bioreactor drives high yield production of functional hiPSC-like hepatocytes for advanced liver disease modelling. Sci Rep. 2024. 14(1): 24599. doi:10.1038/s41598-024-75582-z
  10. Costa MHG, Carrondo I, Isidro IA, Serra M. Harnessing Raman spectroscopy for cell therapy bioprocessing. Biotechnol Adv. 2024. 77: 108472. doi:10.1016/j.biotechadv.2024.108472
  11. Domenici G, Lopes NF, Trindade G, Ramella Gal I, Miret Minard J, Rebelo SP, Freitas C, Duarte N, Brito C. Assessing novel antibody-based therapies in reconstructive 3D cell models of the tumor microenvironment. Adv Biol (Weinh). 2024. 8(12): e2400431. doi:10.1002/adbi.202400431
  12. Lemos L, Antas P, Ferreira IS, Santos IP, Felgueiras B, Gomes CM, Brito C, Seabra MC, Tenreiro S. Modelling neurodegeneration and inflammation in early diabetic retinopathy using 3D human retinal organoids. In Vitro Models. 2024. 3(1): 33–48. doi:10.1007/s44164‑024‑00068‑1
  13. Nascimento A, Faria TQ, Bollmann F, Noverraz M, Pressac G, Roldão A, Peixoto C, Silva RJS. Purification of AAV8 through a scalable two-step monolithic chromatography approach. J Chromatogr A. 2025. 11; 1740: 465586. doi:10.1016/j.chroma.2024.465586
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