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Fundamentals of Bioengineering

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Fundamentals of Bioengineering  

Coordinator
Manuel Carrondo

Objectives
This Curricular Unit will provide an introduction to the important principles that are used in the design and analysis of biopharmaceutical processes. The major objective for students is the attainment of core knowledge in both upstream and downstream engineering aspects of bioprocesses, specific requirements of different products and
awareness of emerging trends in the biopharmaceutical industry.

Syllabus
The first part, Biopharmaceutical Production, will cover fundamental topics in development and design of bioreaction for different biological systems including kinetics, transfer and scaling up-or down. The second part, Purification of Complex Biopharmaceuticals, will focus on aspects of unit operation, design principles and
economics of downstream processes for complex products, the impact of different biological systems on purification strategies and an overview of classical and cutting edge approaches entering the biopharmaceutical industry.
Part I - Biopharmaceutical Production
• Fundamentals in bioreaction
Part II - Purification of Complex Biopharmaceuticals
• Unit operation and design principles for different bioproducts
• Purification processes used in the biopharmaceutical industry
• Impact of host cell/expression system on downstream processing
• Economics of downstream processing; cutting-edge strategies

Evaluation
The evaluation procedure will take place at the end of the CU and consists of a short essay on a given topic, chosen by the student from a list of topics timely provided.

Main Bibliography
  • Shuler ML, Kargi F. Bioprocess Engineering: basic concepts. 2nd Edition Prentice Hall, 2002.
  • Cell culture technology for pharmaceutical and cell-based therapies, Ozturk, S.S., Hu, W.-S. (eds) (2005) Taylor and Francis, Boca Raton, USA.

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