 | | Molecular Machines of LifeCoordinator
Manuela Pereira Objectives
This unit aims at providing the student with a deep knowledge of molecular machines and respective functions.
Specifically it is aimed to,
1- Understand the concept of molecular machines.
2- Know that molecular machines are constituted by biomolecules.
3- Recognize different functions of molecular machines.
4- Integrate the functions of molecular machines in metabolism and cellular processes.
5- Recognize different methodologies to structurally and functionally investigate molecular machines. Syllabus
1- Introduction to the concept of molecular machines as organized molecular structures, which perform physicochemical processes. Integration of the different molecular machines and respective functions in the metabolism and cellular processes.
2- Building and processing machines. Examples: Polymerases, Ribosome, Proteasome, Aminoacyl-tRNA synthetase, Spliciosome, Condensin, T4 DNA packing motor, Helicase/Topisomerase, Mitotic Spindle.
3- Cargo transporters/moving machines. Examples: Kinesin, Myosin, Dynein
4- Cargo membrane transporters/Secreting systems. Examples: TIM/TOM systems, ClpX, Sec and TAT systems, Secreting systems, Injectosome
5- Cellular motility machines. Examples: Flagellum, Cillium, Glideosome,
6- Signal transduction machines. Examples: Voltage dependent anion channels (VDAC), K+ channels, mechanosensitive channels.
7- Energy conserving machines. Examples: Respiratory complexes, ATP synthase, Na+/H+ antiporters, Bacteriorhodopsine. Main Bibliography - Lehninger, Principles of Biochemistry by DL Nelson and MM Cox, 2000, 3th edition, ISBN 1-57259-153-6.
- Biophysical Chemistry: Part I, II e III by Charles R. Cantor, Paul R. Schimmel, W. H. Freeman, 1980, 1st edition, ISBN 978-0-7167-1188-9, 978-0-7167-1190-2, 978-0-7167-1192-6.
- The Machinery of Life by David S. Goodsell, 2009, 2nd edition, ISBN 978-0387849249.
- Molecular Machines in Biology: Workshop of the Cell by Joachim Frank, 2011, ISBN 978-0521194280.
- Molecular Machines Benoit Roux, 2011, 1st edition, ISBN 978-9814343442.
- How Proteins Work by Mike Williamson, 2011, 1st edition, ISBN 978-0815344469.
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